About   Help   FAQ
Tns2 Gene Detail
Summary
  • Symbol
    Tns2
  • Name
    tensin 2
  • Synonyms
    nep, nph, Tenc1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2387586
    NCBI Gene: 209039
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:102008848-102024836 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 57.29 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    34 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2387586
 protein coding gene Chr15:102006910-102024836 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022398
 protein coding gene Chr15:104243215-104256628 (+)
A/J MGP_AJ_G0022360
 protein coding gene Chr15:100162309-100175921 (+)
AKR/J MGP_AKRJ_G0022335
 protein coding gene Chr15:103193521-103206934 (+)
BALB/cJ MGP_BALBcJ_G0022364
 protein coding gene Chr15:100205840-100219253 (+)
C3H/HeJ MGP_C3HHeJ_G0022131
 protein coding gene Chr15:103264512-103278187 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022813
 protein coding gene Chr15:108131489-108144902 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020336
 protein coding gene Chr15:95937926-95951608 (+)
CAST/EiJ MGP_CASTEiJ_G0021657
 protein coding gene Chr15:104121433-104134861 (+)
CBA/J MGP_CBAJ_G0022100
 protein coding gene Chr15:111907723-111921350 (+)
DBA/2J MGP_DBA2J_G0022231
 protein coding gene Chr15:99449224-99462637 (+)
FVB/NJ MGP_FVBNJ_G0022207
 protein coding gene Chr15:98504793-98518206 (+)
LP/J MGP_LPJ_G0022300
 protein coding gene Chr15:104408495-104421908 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022229
 protein coding gene Chr15:115508397-115521810 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022825
 protein coding gene Chr15:103213315-103226728 (+)
PWK/PhJ MGP_PWKPhJ_G0021397
 protein coding gene Chr15:99597843-99611265 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021229
 protein coding gene Chr15:103060604-103074003 (+)
WSB/EiJ MGP_WSBEiJ_G0021707
 protein coding gene Chr15:103841342-103854984 (+)



Homology
more
  • Human Ortholog
    TNS2, tensin 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TNS2, tensin 2
  • Synonyms
    C1TEN, C1-TEN, TENC1
  • Links
    NCBI Gene ID: 23371
    neXtProt AC: NX_Q63HR2
    UniProt: Q63HR2

  • Chr Location
    12q13.13; chr12:53046969-53064379 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Tns2 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 1 allele in 1 genetic background
    54 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Affected mice homozygous for a spontaneous deletion show reduced female fertility, increased blood urea nitrogen, low hematocrit, proteinuria, hypoproteinemia, hypercholesterolemia, small kidneys with a yellowish granular surface, glomerular lesions and premature death; some develop systemic edema.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    819
  • Tissues
    28
  • cDNA Data
    71
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037003 Ensembl Gene Model | MGI Sequence Detail 15989 C57BL/6J ±  kb
    transcript ENSMUST00000046144 Ensembl | MGI Sequence Detail 4718 Not Applicable  
    polypeptide ENSMUSP00000041087 Ensembl | MGI Sequence Detail 1407 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 71
      cDNA 71

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1096861
    References
    more
    • Summaries
      All 83
      Developmental Gene Expression 3
      Diseases 2
      Gene Ontology 8
      Phenotypes 54
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:321844 Mochida Y, et al., Piezo2 expression and its alteration by mechanical forces in mouse mesangial cells and renin-producing cells. Sci Rep. 2022 Mar 10;12(1):4197
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory