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Ncoa5 Gene Detail
Summary
  • Symbol
    Ncoa5
  • Name
    nuclear receptor coactivator 5
  • Synonyms
    MGC:28864
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385165
    NCBI Gene: 228869
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:164842277-164876787 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 85.32 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    681 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385165
 protein coding gene Chr2:164842273-164876794 (-)
129S1/SvImJ ENSMUSG00200017099
 protein coding gene Chr2:161731286-161754125 (-)
A/J ENSMUSG00195024362
 protein coding gene Chr2:162063427-162086537 (-)
AKR/J ENSMUSG00220012063
 protein coding gene Chr2:161392835-161415647 (-)
BALB/cJ ENSMUSG00180047933
 protein coding gene Chr2:161517159-161540267 (-)
C3H/HeJ ENSMUSG00175050967
 protein coding gene Chr2:162267758-162290855 (-)
C57BL/6NJ ENSMUSG00215029941
 protein coding gene Chr2:161715199-161738058 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024679
 protein coding gene Chr2:156948799-156983436 (-)
CAST/EiJ ENSTCUG00005045143
 protein coding gene Chr2:160634405-160657237 (-)
CBA/J ENSMUSG00210016429
 protein coding gene Chr2:162197752-162220864 (-)
DBA/2J ENSMUSG00185043467
 protein coding gene Chr2:161934874-161957971 (-)
FVB/NJ ENSMUSG00205030613
 protein coding gene Chr2:160955796-160978895 (-)
JF1/MsJ ENSUMUG00000008083
 protein coding gene Chr2:161580089-161602920 (-)
LP/J ENSMUSG00230040196
 protein coding gene Chr2:163492362-163515199 (-)
NOD/ShiLtJ ENSMUSG00190030589
 protein coding gene Chr2:161602629-161625737 (-)
NZO/HlLtJ ENSMUSG00225052703
 protein coding gene Chr2:171497207-171520310 (-)
PWK/PhJ ENSLUMG00010042033
 protein coding gene Chr2:161477057-161498968 (-)
SPRET/EiJ ENSMSPG00010028120
 protein coding gene Chr2:164237322-164271850 (-)
WSB/EiJ ENSIUOG00005044126
 protein coding gene Chr2:161329063-161352172 (-)



Homology
more
  • Human Ortholog
    NCOA5, nuclear receptor coactivator 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NCOA5, nuclear receptor coactivator 5
  • Synonyms
    bA465L10.6, CIA
  • Links
    NCBI Gene ID: 57727
    UniProt: Q9HCD5

  • Chr Location
    20q13.12; chr20:46060985-46089962 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 2 alleles in 3 genetic backgrounds
    9 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice heterozygous for a knock-out allele exhibit impaired glucose homeostasis, liver dysplasia, increased hepatocellular carcinoma incidence, and male infertility associated with abnormal sperm motility, progression and morphology and increased IL-6 expression in the epididymis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    723
  • Tissues
    52
  • cDNA Data
    94
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039804 Ensembl Gene Model | MGI Sequence Detail 34511 C57BL/6J ±  kb
    transcript ENSMUST00000040381 Ensembl | MGI Sequence Detail 3179 Not Applicable  
    polypeptide ENSMUSP00000046388 Ensembl | MGI Sequence Detail 579 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000011044 nuclear receptor coactivator 5
      (term hierarchy)
    • InterPro Domains
      IPR036621 Anticodon-binding domain superfamily
      IPR052600 Nuclear receptor coactivator 5
    • GlyGen
      Q91W39 5 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (4 sites)
    Molecular
    Reagents
    less
    • All nucleic 95
      cDNA 95

      Microarray probesets 3
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 14
    • Earliest
      J:182418 Sauve F, et al., CIA, a novel estrogen receptor coactivator with a bifunctional nuclear receptor interacting determinant. Mol Cell Biol. 2001 Jan;21(1):343-53
    • Latest
      J:358041 Zhang Y, et al., NCOA5 Haploinsufficiency in Myeloid-Lineage Cells Sufficiently Causes Nonalcoholic Steatohepatitis and Hepatocellular Carcinoma. Cell Mol Gastroenterol Hepatol. 2024;17(1):1-27
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory