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Trim31 Gene Detail
Summary
  • Symbol
    Trim31
  • Name
    tripartite motif-containing 31
  • Synonyms
    HCG1, MGC:37625
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385051
    NCBI Gene: 224762
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:37209022-37221109 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 19.16 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385051
 protein coding gene Chr17:37209010-37221109 (+)
129S1/SvImJ ENSMUSG00200051204
 protein coding gene Chr17:32663205-32675374 (+)
A/J ENSMUSG00195046051
 protein coding gene Chr17:33872465-33884547 (+)
AKR/J ENSMUSG00220050538
 protein coding gene Chr17:32604755-32616883 (+)
BALB/cJ ENSMUSG00180042609
 protein coding gene Chr17:33352840-33365014 (+)
C3H/HeJ ENSMUSG00175041101
 protein coding gene Chr17:32545298-32557415 (+)
C57BL/6NJ ENSMUSG00215052056
 protein coding gene Chr17:32507338-32519441 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021557
 protein coding gene Chr17:33892231-33904727 (+)
CAST/EiJ ENSTCUG00005048871
 protein coding gene Chr17:33743779-33755897 (+)
CBA/J ENSMUSG00210038007
 protein coding gene Chr17:32281517-32293637 (+)
DBA/2J ENSMUSG00185051912
 protein coding gene Chr17:35333781-35345952 (+)
FVB/NJ ENSMUSG00205026634
 protein coding gene Chr17:32867395-32879475 (+)
JF1/MsJ ENSUMUG00000048556
 protein coding gene Chr17:34275885-34288078 (+)
LP/J ENSMUSG00230054108
 protein coding gene Chr17:36458076-36470246 (+)
NOD/ShiLtJ ENSMUSG00190030676
 protein coding gene Chr17:32547677-32559760 (+)
NZO/HlLtJ ENSMUSG00225051966
 protein coding gene Chr17:38414692-38426745 (+)
PWK/PhJ ENSLUMG00010034639
 protein coding gene Chr17:32156413-32168626 (+)
SPRET/EiJ ENSMSPG00010031428
 protein coding gene Chr17:33415002-33426791 (+)
WSB/EiJ ENSIUOG00005047479
 protein coding gene Chr17:33375056-33387173 (+)



Homology
more
  • Human Ortholog
    TRIM31, tripartite motif containing 31
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRIM31, tripartite motif containing 31
  • Synonyms
    C6orf13, HCG1, HCGI, RNF
  • Links
    NCBI Gene ID: 11074
    UniProt: Q9BZY9

  • Chr Location
    6p22.1; chr6:30102886-30113090 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout exacerbates the immune response after induced inflammation and in induced peritonitis and reduces the immune response in induced colitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    620
  • Tissues
    9
  • cDNA Data
    6
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 224762 NCBI Gene Model | MGI Sequence Detail 12088 C57BL/6J ±  kb
    transcript NM_146077 RefSeq | MGI Sequence Detail 2248 C57BL/6  
    polypeptide Q8R0K2 UniProt | EBI | MGI Sequence Detail 507 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 6

      Microarray probesets 2
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 2
      Gene Ontology 12
      Phenotypes 10
    • Earliest
      J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
    • Latest
      J:366444 Xue J, et al., Trim31 deficiency exacerbates airway inflammation in asthma by enhancing the activation of the NLRP3 inflammasome. Int Immunopharmacol. 2024 Sep 10;138:112591
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory