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Prmt7 Gene Detail
Summary
  • Symbol
    Prmt7
  • Name
    protein arginine N-methyltransferase 7
  • Synonyms
    4933402B05Rik, MGC:7929
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384879
    NCBI Gene: 214572
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:106937686-106978326 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 53.11 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1188 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384879
 protein coding gene Chr8:106937568-106979426 (+)
129S1/SvImJ ENSMUSG00200012472
 protein coding gene Chr8:101217458-101259317 (+)
A/J ENSMUSG00195019817
 protein coding gene Chr8:101539987-101581844 (+)
AKR/J ENSMUSG00220014761
 protein coding gene Chr8:101682873-101724735 (+)
BALB/cJ ENSMUSG00180020549
 protein coding gene Chr8:101545784-101587643 (+)
C3H/HeJ ENSMUSG00175023394
 protein coding gene Chr8:101602458-101644316 (+)
C57BL/6NJ ENSMUSG00215024842
 protein coding gene Chr8:101216805-101258665 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031516
 protein coding gene Chr8:97349405-97392854 (+)
CAST/EiJ ENSTCUG00005021608
 protein coding gene Chr8:100984059-101029942 (+)
CBA/J ENSMUSG00210028340
 protein coding gene Chr8:101530179-101572038 (+)
DBA/2J ENSMUSG00185005488
 protein coding gene Chr8:107638916-107680779 (+)
FVB/NJ ENSMUSG00205014079
 protein coding gene Chr8:100514521-100556380 (+)
JF1/MsJ ENSUMUG00000009094
 protein coding gene Chr8:109972088-110013944 (+)
LP/J ENSMUSG00230033535
 protein coding gene Chr8:111319307-111361166 (+)
NOD/ShiLtJ ENSMUSG00190020309
 protein coding gene Chr8:101669337-101711195 (+)
NZO/HlLtJ ENSMUSG00225022398
 protein coding gene Chr8:114669850-114711705 (+)
PWK/PhJ ENSLUMG00010003886
 protein coding gene Chr8:101468228-101510272 (+)
SPRET/EiJ ENSMSPG00010030648
 protein coding gene Chr8:103536800-103579186 (+)
WSB/EiJ ENSIUOG00005031839
 protein coding gene Chr8:102349567-102391484 (+)



Homology
more
  • Human Ortholog
    PRMT7, protein arginine methyltransferase 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRMT7, protein arginine methyltransferase 7
  • Synonyms
    SBIDDS
  • Links
    NCBI Gene ID: 54496
    UniProt: Q9NVM4

  • Chr Location
    16q22.1; chr16:68310916-68360870 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    38 phenotypes from 3 alleles in 3 genetic backgrounds
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced body weight, increased epididymal fat pad weight, impaired myoblast differentiation, reduced satellite cells, early cellular replicative senescence in muscles and reduced muscle regeneration following injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    45
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    608
  • Tissues
    10
  • cDNA Data
    7
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 214572 NCBI Gene Model | MGI Sequence Detail 40641 C57BL/6J ±  kb
    transcript NM_145404 RefSeq | MGI Sequence Detail 2269 FVB/N  
    polypeptide Q922X9 UniProt | EBI | MGI Sequence Detail 692 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 10
      Antibodies 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1918262
    References
    more
    • Summaries
      All 76
      Developmental Gene Expression 9
      Gene Ontology 10
      Phenotypes 28
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:372756 Wang YJ, et al., PRMT5-mediated homologous recombination repair is essential to maintain genomic integrity of neural progenitor cells. Cell Mol Life Sci. 2024 Mar 8;81(1):123
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory