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Herc1 Gene Detail
Summary
  • Symbol
    Herc1
  • Name
    HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
  • Synonyms
    2810449H11Rik, D130015N03Rik, MGC:7618, tbl
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384589
    NCBI Gene: 235439
  • Alliance
    genome feature page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:66257732-66416057 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 35.86 cM, cytoband D
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2611 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384589
 protein coding gene Chr9:66257694-66416057 (+)
129S1/SvImJ ENSMUSG00200043118
 protein coding gene Chr9:63356086-63514255 (+)
A/J ENSMUSG00195025013
 protein coding gene Chr9:63076790-63235032 (+)
AKR/J ENSMUSG00220039886
 protein coding gene Chr9:63214835-63373065 (+)
BALB/cJ ENSMUSG00180015398
 protein coding gene Chr9:63203373-63361608 (+)
C3H/HeJ ENSMUSG00175011813
 protein coding gene Chr9:63210083-63368306 (+)
C57BL/6NJ ENSMUSG00215024984
 protein coding gene Chr9:63198867-63357094 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032378
 protein coding gene Chr9:63548037-63707327 (+)
CAST/EiJ ENSTCUG00005027073
 protein coding gene Chr9:63112990-63272261 (+)
CBA/J ENSMUSG00210013957
 protein coding gene Chr9:63296084-63454308 (+)
DBA/2J ENSMUSG00185032609
 protein coding gene Chr9:63322187-63480399 (+)
FVB/NJ ENSMUSG00205030059
 protein coding gene Chr9:63641311-63801257 (+)
JF1/MsJ ENSUMUG00000029909
 protein coding gene Chr9:63397285-63557403 (+)
LP/J ENSMUSG00230020413
 protein coding gene Chr9:63555011-63713174 (+)
NOD/ShiLtJ ENSMUSG00190021301
 protein coding gene Chr9:63406341-63564552 (+)
NZO/HlLtJ ENSMUSG00225045682
 protein coding gene Chr9:63621787-63780000 (+)
PWK/PhJ ENSLUMG00010025737
 protein coding gene Chr9:63343132-63502829 (+)
SPRET/EiJ ENSMSPG00010017140
 protein coding gene Chr9:64416171-64578358 (+)
WSB/EiJ ENSIUOG00005022135
 protein coding gene Chr9:62810723-62968954 (+)



Homology
more
  • Human Ortholog
    HERC1, HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HERC1, HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
  • Synonyms
    MDFPMR, p532, p619
  • Links
    NCBI Gene ID: 8925
    UniProt: Q15751

  • Chr Location
    15q22.31; chr15:63608618-63833948 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    34 phenotypes from 3 alleles in 3 genetic backgrounds
    1 images
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for this spontaneous mutation exhibit an abnormal cerebellar Purkinje cell layer and Purkinje cell degeneration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    766
  • Tissues
    22
  • cDNA Data
    15
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038664 Ensembl Gene Model | MGI Sequence Detail 158326 C57BL/6J ±  kb
    transcript ENSMUST00000042824 Ensembl | MGI Sequence Detail 15153 Not Applicable  
    polypeptide ENSMUSP00000044801 Ensembl | MGI Sequence Detail 4859 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • EC
      2.3.2.26
    • InterPro Domains
      IPR001870 B30.2/SPRY domain
      IPR043136 B30.2/SPRY domain superfamily
      IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
      IPR051625 Diverse Signaling and Regulatory Domain-Containing Protein
      IPR042469 E3 ubiquitin-protein ligase HECTD3
      IPR050672 F-box/SPRY and SOCS box protein families
      IPR000569 HECT domain
      IPR035983 HECT, E3 ligase catalytic domain
      IPR035768 HERC1, SPRY domain
      IPR051179 Multifunctional WD repeat-containing protein
      IPR058923 RCC1-like domain
      IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
      IPR000408 Regulator of chromosome condensation, RCC1
      IPR003877 SPRY domain
      IPR001680 WD40 repeat
      IPR019775 WD40 repeat, conserved site
      IPR036322 WD40-repeat-containing domain superfamily
      IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    • GlyGen
      E9PZP8 5 sites, 3 N-linked glycans (3 sites), 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 16

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1925757, MGI:2442235, MGI:3613032
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 2
      Gene Ontology 8
      Phenotypes 24
    • Earliest
      J:106414 Wassef M, et al., Cerebellar mutations affecting the postnatal survival of Purkinje cells in the mouse disclose a longitudinal pattern of differentially sensitive cells. Dev Biol. 1987 Dec;124(2):379-89
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory