Herc1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Herc1
HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
MGI:2384589

33 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Herc1^{em2(IMPC)Wtsi}/Herc1^{em2(IMPC)Wtsi} C57BL/6N-Herc1^{em2(IMPC)Wtsi}/Wtsi	abnormal lens morphology	J:211773
	cataract	J:211773
Herc1^{em3(IMPC)Wtsi}/Herc1^{em3(IMPC)Wtsi} C57BL/6N-Herc1^{em3(IMPC)Wtsi}/Wtsi	abnormal auditory brainstem response	J:211773
	abnormal retina morphology	J:211773
	decreased bone mineral content	J:211773
	decreased bone mineral density	J:211773
	decreased circulating glucose level	J:211773
	decreased lean body mass	J:211773
	impaired glucose tolerance	J:211773
	increased circulating alkaline phosphatase level	J:211773
	increased circulating amylase level	J:211773
	increased circulating chloride level	J:211773
	increased circulating insulin level	J:211773
	increased circulating sodium level	J:211773
	increased eosinophil cell number	J:211773
	increased fasting circulating glucose level	J:211773
	increased leukocyte cell number	J:211773
	increased Ly6C high monocyte number	J:211773
	increased Ly6C low monocyte number	J:211773
	increased mean platelet volume	J:211773
	increased monocyte cell number	J:211773
	increased red blood cell distribution width	J:211773
	increased total body fat amount	J:211773
	male infertility	J:211773
Herc1^tbl/Herc1^tbl involves: DW/J	abnormal cerebellar Purkinje cell layer	J:23733
	abnormal gait	J:161738
	abnormal Purkinje cell morphology	J:106414
	decreased body height	J:161738
	decreased Purkinje cell number	J:106414
	decreased survivor rate	J:161738
	impaired coordination	J:161738
	limb grasping	J:161738
	Purkinje cell degeneration	J:23733

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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