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Zfp768 Gene Detail
Summary
  • Symbol
    Zfp768
  • Name
    zinc finger protein 768
  • Synonyms
    MGC:31345
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384582
    NCBI Gene: 233890
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:126941967-126944486 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 69.47 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    127 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384582
 protein coding gene Chr7:126941967-126944761 (-)
129S1/SvImJ ENSMUSG00200021773
 protein coding gene Chr7:113454939-113457733 (-)
A/J ENSMUSG00195041449
 protein coding gene Chr7:117971041-117973835 (-)
AKR/J ENSMUSG00220018617
 protein coding gene Chr7:111403871-111406665 (-)
BALB/cJ ENSMUSG00180010886
 protein coding gene Chr7:114644691-114647485 (-)
C3H/HeJ ENSMUSG00175013736
 protein coding gene Chr7:115371651-115374445 (-)
C57BL/6NJ ENSMUSG00215029837
 protein coding gene Chr7:114651650-114654444 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030498
 protein coding gene Chr7:129387770-129390575 (-)
CAST/EiJ ENSTCUG00005047139
 protein coding gene Chr7:117885126-117887920 (-)
CBA/J ENSMUSG00210022594
 protein coding gene Chr7:115132748-115135542 (-)
DBA/2J ENSMUSG00185039249
 protein coding gene Chr7:119445563-119448357 (-)
FVB/NJ ENSMUSG00205016150
 protein coding gene Chr7:115088507-115091301 (-)
JF1/MsJ ENSUMUG00000033232
 protein coding gene Chr7:124512181-124514975 (-)
LP/J ENSMUSG00230051515
 protein coding gene Chr7:125554889-125557683 (-)
NOD/ShiLtJ ENSMUSG00190015959
 protein coding gene Chr7:115292210-115295004 (-)
NZO/HlLtJ ENSMUSG00225010240
 protein coding gene Chr7:123784914-123787708 (-)
PWK/PhJ ENSLUMG00010029493
 protein coding gene Chr7:113648814-113651608 (-)
SPRET/EiJ ENSMSPG00010012271
 protein coding gene Chr7:114907052-114909846 (-)
WSB/EiJ ENSIUOG00005030740
 protein coding gene Chr7:115993494-115996288 (-)



Homology
more
  • Human Ortholog
    ZNF768, zinc finger protein 768
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZNF768, zinc finger protein 768
  • Links
    NCBI Gene ID: 79724
    UniProt: Q9H5H4

  • Chr Location
    16p11.2; chr16:30524004-30532477 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele are viable but show a mild growth defect early in life, increased radiosensitivity, and reduced lung tumor development in response to oncogenic KRAS. Mouse embryonic fibroblasts exhibit higher p53 levels and premature senescence after DNA damage and replicative stress.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    653
  • Tissues
    33
  • cDNA Data
    31
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 233890 NCBI Gene Model | MGI Sequence Detail 2520 C57BL/6J ±  kb
    transcript NM_146202 RefSeq | MGI Sequence Detail 2268 FVB/N  
    polypeptide Q8R0T2 UniProt | EBI | MGI Sequence Detail 568 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 32
      cDNA 32
      Antibodies 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 6
    • Earliest
      J:91257 Gray PA, et al., Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
    • Latest
      J:367791 Poirier A, et al., Generation and characterization of a Cre-inducible ZNF768 overexpression mouse model. Sci Rep. 2025 Jun 5;15(1):19792
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory