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Oas1h Gene Detail
Summary
  • Symbol
    Oas1h
  • Name
    2'-5' oligoadenylate synthetase 1H
  • Feature Type
    protein coding gene
  • IDs
    MGI:2180853
    NCBI Gene: 246729
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr5:120999485-121011569 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 60.64 cM, cytoband F
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    11 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2180853
 protein coding gene Chr5:120999484-121011569 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030018
 protein coding gene Chr5:124283668-124294259 (+)
A/J MGP_AJ_G0029982
 protein coding gene Chr5:119121079-119139960 (+)
AKR/J MGP_AKRJ_G0029920
 protein coding gene Chr5:122975460-123034557 (+)
BALB/cJ MGP_BALBcJ_G0029993
 protein coding gene Chr5:120529647-120541714 (+)
C3H/HeJ MGP_C3HHeJ_G0029713
 protein coding gene Chr5:123546189-123558033 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030448
 protein coding gene Chr5:128967511-128978278 (+)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0029121
 protein coding gene Chr5:122715160-122728744 (+)
CBA/J MGP_CBAJ_G0029681
 protein coding gene Chr5:134003060-134056062 (+)
DBA/2J MGP_DBA2J_G0029831
 protein coding gene Chr5:119221469-119232194 (+)
FVB/NJ MGP_FVBNJ_G0029787
 protein coding gene Chr5:118160370-118171646 (+)
LP/J MGP_LPJ_G0029919
 protein coding gene Chr5:124753211-124763889 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029817
 protein coding gene Chr5:137937652-137999043 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030489
 protein coding gene Chr5:122548007-122558673 (+)
PWK/PhJ MGP_PWKPhJ_G0028834
 protein coding gene Chr5:117997569-118004439 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028673
 protein coding gene Chr5:120271361-120277341 (+)
WSB/EiJ MGP_WSBEiJ_G0029196
 protein coding gene Chr5:123152502-123163782 (+)



Homology
more
  • Human Ortholog
    OAS1, 2'-5'-oligoadenylate synthetase 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OAS1, 2'-5'-oligoadenylate synthetase 1
  • Synonyms
    E18/E16, IFI-4, IMD100, OIAS, OIASI
  • Links
    NCBI Gene ID: 4938
    neXtProt AC: NX_P00973
    UniProt: P00973

  • Chr Location
    12q24.13; chr12:112905856-112933219 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human OAS1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    733
  • Tissues
    17
  • cDNA Data
    8
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 246729 NCBI Gene Model | MGI Sequence Detail 12085 C57BL/6J ±  kb
transcript NM_145228 RefSeq | MGI Sequence Detail 1708 ZRU/MplStud  
polypeptide NP_660263 RefSeq | MGI Sequence Detail 369 ZRU/MplStud  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • InterPro Domains
    IPR006116 2-5OAS/ClassI-CCAase, nucleotidyltransferase domain
    IPR018952 2'-5'-oligoadenylate synthetase 1, domain 2/C-terminal
    IPR043519 Nucleotidyltransferase superfamily
    IPR002934 Polymerase, nucleotidyl transferase domain
Molecular
Reagents
less
  • All nucleic 10
    Genomic 1
    cDNA 8
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 28
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 8
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:192649 Kristiansen H, et al., The oligoadenylate synthetase family: an ancient protein family with multiple antiviral activities. J Interferon Cytokine Res. 2011 Jan;31(1):41-7
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory