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Slc8b1 Gene Detail
Summary
  • Symbol
    Slc8b1
  • Name
    solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
  • Synonyms
    NCKX6, NCLX, Slc24a6
  • Feature Type
    protein coding gene
  • IDs
    MGI:2180781
    NCBI Gene: 170756
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:120649233-120672089 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 60.63 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    10 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2180781
 protein coding gene Chr5:120649233-120672089 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030005
 protein coding gene Chr5:123867216-123891313 (+)
A/J MGP_AJ_G0029969
 protein coding gene Chr5:118755434-118779232 (+)
AKR/J MGP_AKRJ_G0029908
 protein coding gene Chr5:122586180-122609050 (+)
BALB/cJ MGP_BALBcJ_G0029980
 protein coding gene Chr5:120171472-120194572 (+)
C3H/HeJ MGP_C3HHeJ_G0029700
 protein coding gene Chr5:123118301-123142163 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030435
 protein coding gene Chr5:128530526-128556089 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027661
 protein coding gene Chr5:113463640-113486958 (+)
CAST/EiJ MGP_CASTEiJ_G0029109
 protein coding gene Chr5:122245918-122269086 (+)
CBA/J MGP_CBAJ_G0029668
 protein coding gene Chr5:133517826-133540699 (+)
DBA/2J MGP_DBA2J_G0029818
 protein coding gene Chr5:118840223-118863033 (+)
FVB/NJ MGP_FVBNJ_G0029774
 protein coding gene Chr5:117761684-117785521 (+)
LP/J MGP_LPJ_G0029906
 protein coding gene Chr5:124337462-124363024 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029805
 protein coding gene Chr5:137493238-137516109 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030476
 protein coding gene Chr5:122159605-122186132 (+)
PWK/PhJ MGP_PWKPhJ_G0028822
 protein coding gene Chr5:117599851-117623539 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028661
 protein coding gene Chr5:119824106-119851048 (+)
WSB/EiJ MGP_WSBEiJ_G0029184
 protein coding gene Chr5:122751451-122776150 (+)



Homology
more
  • Human Ortholog
    SLC8B1, solute carrier family 8 member B1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC8B1, solute carrier family 8 member B1
  • Synonyms
    NCKX6, NCLX, SLC24A6
  • Links
    NCBI Gene ID: 80024
    neXtProt AC: NX_Q6J4K2
    UniProt: Q6J4K2

  • Chr Location
    12q24.13; chr12:113298759-113359493 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an inducible conditional allele exhibit premature death with cardiac failure, fibrosis, hypertrophy, and swollen mitochondria in tamoxifen-treated mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    44
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    806
  • Tissues
    96
  • cDNA Data
    20
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 170756 NCBI Gene Model | MGI Sequence Detail 22857 C57BL/6J ±  kb
    transcript NM_133221 RefSeq | MGI Sequence Detail 2893 C57BL/6  
    polypeptide Q925Q3 UniProt | EBI | MGI Sequence Detail 585 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000015003 mitochondrial sodium/calcium exchanger protein
      (term hierarchy)
    • InterPro Domains
      IPR044880 NCX, central ion-binding domain superfamily
      IPR004837 Sodium/calcium exchanger membrane region
    Molecular
    Reagents
    less
    • All nucleic 25
      Genomic 4
      cDNA 20
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 4
      Gene Ontology 12
      Phenotypes 26
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:341543 Meng TG, et al., NLRP14 Safeguards Calcium Homeostasis via Regulating the K27 Ubiquitination of Nclx in Oocyte-to-Embryo Transition. Adv Sci (Weinh). 2023 Sep;10(27):e2301940
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory