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Polq Gene Detail
Summary
  • Symbol
    Polq
  • Name
    polymerase (DNA directed), theta
  • Synonyms
    A430110D14Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2155399
    NCBI Gene: 77782
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:36832148-36915779 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 26.32 cM, cytoband B4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1841 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2155399
 protein coding gene Chr16:36832104-36922321 (+)
129S1/SvImJ ENSMUSG00200027514
 protein coding gene Chr16:33767848-33854115 (+)
A/J ENSMUSG00195010259
 protein coding gene Chr16:33314302-33400542 (+)
AKR/J ENSMUSG00220025766
 protein coding gene Chr16:33691924-33778164 (+)
BALB/cJ ENSMUSG00180012300
 protein coding gene Chr16:33529914-33616149 (+)
C3H/HeJ ENSMUSG00175030082
 protein coding gene Chr16:33750279-33836513 (+)
C57BL/6NJ ENSMUSG00215016144
 protein coding gene Chr16:33603451-33689722 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020725
 protein coding gene Chr16:34052493-34132666 (+)
CAST/EiJ ENSTCUG00005028332
 protein coding gene Chr16:34022539-34114973 (+)
CBA/J ENSMUSG00210027194
 protein coding gene Chr16:33807357-33893594 (+)
DBA/2J ENSMUSG00185023226
 protein coding gene Chr16:33710386-33796621 (+)
FVB/NJ ENSMUSG00205014447
 protein coding gene Chr16:33666798-33773101 (+)
JF1/MsJ ENSUMUG00000018962
 protein coding gene Chr16:33925197-34010660 (+)
LP/J ENSMUSG00230027124
 protein coding gene Chr16:36282589-36368823 (+)
NOD/ShiLtJ ENSMUSG00190019572
 protein coding gene Chr16:33828731-33914961 (+)
NZO/HlLtJ ENSMUSG00225038797
 protein coding gene Chr16:39381935-39468166 (+)
PWK/PhJ ENSLUMG00010026627
 protein coding gene Chr16:33832961-33918231 (+)
SPRET/EiJ ENSMSPG00010016700
 protein coding gene Chr16:33817073-33903039 (+)
WSB/EiJ ENSIUOG00005026564
 protein coding gene Chr16:33880048-33972471 (+)



Homology
more
  • Human Ortholog
    POLQ, DNA polymerase theta
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    POLQ, DNA polymerase theta
  • Synonyms
    PRO0327
  • Links
    NCBI Gene ID: 10721
    UniProt: O75417

  • Chr Location
    3q13.33; chr3:121431426-121546002 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 5 alleles in 5 genetic backgrounds
    1 phenotype from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Animals carrying a homozygous mutation at this locus display elevated levels of chromosomal damage.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    88
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    616
  • Tissues
    14
  • cDNA Data
    45
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034206 Ensembl Gene Model | MGI Sequence Detail 83632 C57BL/6J ±  kb
    transcript ENSMUST00000054034 Ensembl | MGI Sequence Detail 8552 Not Applicable  
    polypeptide ENSMUSP00000059757 Ensembl | MGI Sequence Detail 2544 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 46
      cDNA 45
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1925032
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 2
      Gene Ontology 18
      Phenotypes 25
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:390622 Atkins J, et al., ADH5/ALDH2 dehydrogenases and DNA polymerase theta protect normal and malignant hematopoietic cells from formaldehyde challenge: therapeutic implications. Leukemia. 2025 Sep;39(9):2152-2162
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory