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Kcnn3 Gene Detail
Summary
  • Symbol
    Kcnn3
  • Name
    potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
  • Synonyms
    SK3, small conductance calcium-activated potassium channel 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2153183
    NCBI Gene: 140493
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:89427471-89579801 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 39.16 cM, cytoband F2
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    3790 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2153183
 protein coding gene Chr3:89427471-89582439 (+)
129S1/SvImJ ENSMUSG00200039285
 protein coding gene Chr3:86282732-86430377 (+)
A/J ENSMUSG00195051303
 protein coding gene Chr3:86297765-86445506 (+)
AKR/J ENSMUSG00220048056
 protein coding gene Chr3:86252322-86400038 (+)
BALB/cJ ENSMUSG00180046335
 protein coding gene Chr3:86386089-86534312 (+)
C3H/HeJ ENSMUSG00175043954
 protein coding gene Chr3:86230371-86378102 (+)
C57BL/6NJ ENSMUSG00215049199
 protein coding gene Chr3:86670496-86818127 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025214
 protein coding gene Chr3:82252465-82412259 (+)
CAST/EiJ ENSTCUG00005047102
 protein coding gene Chr3:85745260-85893782 (+)
CBA/J ENSMUSG00210040831
 protein coding gene Chr3:86368006-86515726 (+)
DBA/2J ENSMUSG00185048710
 protein coding gene Chr3:86474514-86622736 (+)
FVB/NJ ENSMUSG00205047294
 protein coding gene Chr3:85291999-85439700 (+)
JF1/MsJ ENSUMUG00000028518
 protein coding gene Chr3:86077911-86226327 (+)
LP/J ENSMUSG00230025629
 protein coding gene Chr3:88504023-88651654 (+)
NOD/ShiLtJ ENSMUSG00190035386
 protein coding gene Chr3:86752919-86901312 (+)
NZO/HlLtJ ENSMUSG00225007464
 protein coding gene Chr3:91259312-91406836 (+)
PWK/PhJ ENSLUMG00010046070
 protein coding gene Chr3:86119972-86268619 (+)
SPRET/EiJ ENSMSPG00010049265
 protein coding gene Chr3:86986651-87137067 (+)
WSB/EiJ ENSIUOG00005049680
 protein coding gene Chr3:86774479-86922569 (+)



Homology
more
  • Human Ortholog
    KCNN3, potassium calcium-activated channel subfamily N member 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCNN3, potassium calcium-activated channel subfamily N member 3
  • Synonyms
    hSK3, KCa2.3, SK3, SKCA3, ZLS3
  • Links
    NCBI Gene ID: 3782
    UniProt: Q9UGI6

  • Chr Location
    1q21.3; chr1:154697455-154870281 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human KCNN3 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 3 genetic backgrounds
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an insertion of a tetracycline-regulated gene switch display no overt phenotype when expression is abolished by doxycycline treatment; in contrast, untreated homozygotes show abnormal respiratory responses to hypoxia, impaired parturition, and pregnancy-related premature death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    627
  • Tissues
    18
  • cDNA Data
    16
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 140493 NCBI Gene Model | MGI Sequence Detail 152331 C57BL/6J ±  kb
transcript NM_080466 RefSeq | MGI Sequence Detail 7617 C57BL/6  
polypeptide P58391 UniProt | EBI | MGI Sequence Detail 732 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000000714 small conductance calcium-activated potassium channel protein 3
    (term hierarchy)
  • InterPro Domains
    IPR004178 Calmodulin-binding domain
    IPR015449 Potassium channel, calcium-activated, SK
    IPR013099 Potassium channel domain
    IPR036122 SK, calmodulin-binding domain superfamily
  • GlyGen
    P58391 2 sites, 1 O-linked glycan (2 sites)
Molecular
Reagents
less
  • All nucleic 19
    cDNA 16
    Primer pair 3
    Antibodies 1

    Microarray probesets 2
References
more
  • Summaries
    All 93
    Developmental Gene Expression 4
    Diseases 1
    Gene Ontology 8
    Phenotypes 40
  • Earliest
    J:95064 Bond CT, et al., Respiration and parturition affected by conditional overexpression of the Ca2+-activated K+ channel subunit, SK3. Science. 2000 Sep 15;289(5486):1942-6
  • Latest
    J:384724 Yang H, et al., Roles of lncLingo2 and its derived miR-876-5p in the acquisition of opioid reinforcement. Addict Biol. 2024 Feb;29(2):e13375
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory