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Fbxw11 Gene Detail
Summary
  • Symbol
    Fbxw11
  • Name
    F-box and WD-40 domain protein 11
  • Synonyms
    2310065A07Rik, BTRC2, BTRCP2, Fbxw1b, HOS, mKIAA0696
  • Feature Type
    protein coding gene
  • IDs
    MGI:2144023
    NCBI Gene: 103583
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:32592724-32696816 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 19.02 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2104 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2144023
 protein coding gene Chr11:32592595-32696816 (+)
129S1/SvImJ ENSMUSG00200009237
 protein coding gene Chr11:29629595-29733596 (+)
A/J ENSMUSG00195014068
 protein coding gene Chr11:29545369-29647423 (+)
AKR/J ENSMUSG00220007736
 protein coding gene Chr11:29737661-29840818 (+)
BALB/cJ ENSMUSG00180007901
 protein coding gene Chr11:29561975-29664026 (+)
C3H/HeJ ENSMUSG00175015666
 protein coding gene Chr11:29552870-29655756 (+)
C57BL/6NJ ENSMUSG00215008239
 protein coding gene Chr11:29501334-29605334 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016189
 protein coding gene Chr11:28233007-28342581 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210009484
 protein coding gene Chr11:29440835-29541966 (+)
DBA/2J ENSMUSG00185017846
 protein coding gene Chr11:29631211-29733261 (+)
FVB/NJ ENSMUSG00205017717
 protein coding gene Chr11:29625631-29727681 (+)
JF1/MsJ ENSUMUG00000008888
 protein coding gene Chr11:29873487-29976641 (+)
LP/J ENSMUSG00230003670
 protein coding gene Chr11:30780027-30882066 (+)
NOD/ShiLtJ ENSMUSG00190023642
 protein coding gene Chr11:29697417-29805673 (+)
NZO/HlLtJ ENSMUSG00225030729
 protein coding gene Chr11:32682750-32786060 (+)
PWK/PhJ ENSLUMG00010016736
 protein coding gene Chr11:29528674-29631772 (+)
SPRET/EiJ ENSMSPG00010019056
 protein coding gene Chr11:29913966-30012206 (+)
WSB/EiJ ENSIUOG00005012399
 protein coding gene Chr11:29625092-29728407 (+)



Homology
more
  • Human Ortholog
    FBXW11, F-box and WD repeat domain containing 11
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FBXW11, F-box and WD repeat domain containing 11
  • Synonyms
    BTRC2, BTRCP2, Fbw11, FBW1B, FBXW1B, Hos, NEDJED
  • Links
    NCBI Gene ID: 23291
    UniProt: Q9UKB1

  • Chr Location
    5q35.1; chr5:171861548-172006873 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 3 alleles in 3 genetic backgrounds
    17 phenotypes from multigenic genotypes
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic growth arrest and complete embryonic lethality before E10.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    48
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    629
  • Tissues
    18
  • cDNA Data
    17
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020271 Ensembl Gene Model | MGI Sequence Detail 104093 C57BL/6J ±  kb
transcript ENSMUST00000076383 Ensembl | MGI Sequence Detail 4019 Not Applicable  
polypeptide ENSMUSP00000075721 Ensembl | MGI Sequence Detail 563 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 20
    cDNA 17
    Primer pair 3

    Microarray probesets 4
Other
Accession IDs
less
MGI:1919630
References
more
  • Summaries
    All 67
    Developmental Gene Expression 3
    Gene Ontology 10
    Phenotypes 24
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:379561 Park SJ, et al., A haploinsufficiency restoration strategy corrects neurobehavioral deficits in Nf1+/- mice. J Clin Invest. 2025 Jul 1;135(13)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory