About   Help   FAQ
Adgrl2 Gene Detail
Summary
  • Symbol
    Adgrl2
  • Name
    adhesion G protein-coupled receptor L2
  • Synonyms
    Lec1, Lphh1, Lphn2, mKIAA0786
  • Feature Type
    protein coding gene
  • IDs
    MGI:2139714
    NCBI Gene: 99633
  • Alliance
    genome feature page
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:148521219-148696191 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 74.10 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4754 from dbSNP Build 142
  • Strain Annotations
    30
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2139714
 protein coding gene Chr3:148521219-149150832 (-)
129S1/SvImJ ENSMUSG00200003049
 protein coding gene Chr3:145443093-145445165 (-)
129S1/SvImJ ENSMUSGG00200054841
 protein coding gene Chr3:145443330-145582058 (-)
A/J ENSMUSG00195003393
 protein coding gene Chr3:145577785-145579852 (-)
A/J ENSMUSGG00195055313
 protein coding gene Chr3:145578017-145716377 (-)
AKR/J ENSMUSG00220000366
 protein coding gene Chr3:143984198-143986270 (-)
AKR/J ENSMUSGG00220054617
 protein coding gene Chr3:143984435-144123195 (-)
BALB/cJ ENSMUSGG00180055045
 protein coding gene Chr3:145435853-145574215 (-)
BALB/cJ ENSMUSG00180024231
 protein coding gene Chr3:145435621-145437688 (-)
C3H/HeJ ENSMUSGG00175055105
 protein coding gene Chr3:145025026-145163381 (-)
C3H/HeJ ENSMUSG00175018895
 protein coding gene Chr3:145024794-145026861 (-)
C57BL/6NJ ENSMUSG00215011267
 protein coding gene Chr3:145712446-145714517 (-)
C57BL/6NJ ENSMUSGG00215055572
 protein coding gene Chr3:145712683-145851328 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025733
 protein coding gene Chr3:141914489-142090440 (-)
CAST/EiJ ENSTCUGG00005054208
 protein coding gene Chr3:146107245-146247307 (-)
CBA/J ENSMUSGG00210054764
 protein coding gene Chr3:145674603-145813341 (-)
CBA/J ENSMUSG00210004294
 protein coding gene Chr3:145674366-145676438 (-)
DBA/2J ENSMUSG00185024425
 protein coding gene Chr3:146321095-146323167 (-)
DBA/2J ENSMUSGG00185057866
 protein coding gene Chr3:146321332-146459829 (-)
FVB/NJ ENSMUSGG00205054445
 protein coding gene Chr3:144568389-144707087 (-)
FVB/NJ ENSMUSG00205009075
 protein coding gene Chr3:144568152-144570223 (-)
JF1/MsJ ENSUMUGG00000058558
 protein coding gene Chr3:145086372-145224848 (-)
LP/J ENSMUSGG00230055344
 protein coding gene Chr3:148196779-148335507 (-)
LP/J ENSMUSG00230019093
 protein coding gene Chr3:148196542-148198614 (-)
NOD/ShiLtJ ENSMUSG00190003991
 protein coding gene Chr3:146672089-146674161 (-)
NOD/ShiLtJ ENSMUSGG00190055013
 protein coding gene Chr3:146672326-146810813 (-)
NZO/HlLtJ ENSMUSGG00225055375
 protein coding gene Chr3:150713128-150851469 (-)
NZO/HlLtJ ENSMUSG00225001922
 protein coding gene Chr3:150712896-150714963 (-)
PWK/PhJ ENSLUMGG00010054150
 protein coding gene Chr3:145000062-145138428 (-)
SPRET/EiJ no annotation
WSB/EiJ ENSIUOGG00005053848
 protein coding gene Chr3:145778072-145916719 (-)



Homology
more
  • Human Ortholog
    ADGRL2, adhesion G protein-coupled receptor L2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADGRL2, adhesion G protein-coupled receptor L2
  • Synonyms
    CIRL2, CL2, LEC1, LPHH1, LPHN2
  • Links
    NCBI Gene ID: 23266
    UniProt: O95490

  • Chr Location
    1p31.1; chr1:81306112-81993940 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice die prenatally at fetal stages with cardiac defects. Heterozygous mice exhibit decreased locomotor activity in an open field test.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    711
  • Tissues
    43
  • cDNA Data
    13
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028184 Ensembl Gene Model | MGI Sequence Detail 174973 C57BL/6J ±  kb
    transcript ENSMUST00000197567 Ensembl | MGI Sequence Detail 5585 Not Applicable  
    polypeptide ENSMUSP00000143626 Ensembl | MGI Sequence Detail 1487 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      18 Sequences
    • Protein Ontology
      PR:000001234 adhesion G protein-coupled receptor L2
      (term hierarchy)
    • PDB
      6SKE
    • InterPro Domains
      IPR032471 AGRL2-4 , GAIN subdomain A
      IPR000922 D-galactoside/L-rhamnose binding SUEL lectin domain
      IPR043159 D-galactoside/L-rhamnose binding SUEL lectin domain superfamily
      IPR046338 GAIN domain superfamily
      IPR057244 GAIN, subdomain B
      IPR001879 GPCR, family 2, extracellular hormone receptor domain
      IPR036445 GPCR family 2, extracellular hormone receptor domain superfamily
      IPR003924 GPCR, family 2, latrophilin
      IPR003334 GPCR, family 2, latrophilin, C-terminal
      IPR017981 GPCR, family 2-like, 7TM
      IPR000832 GPCR, family 2, secretin-like
      IPR017983 GPCR, family 2, secretin-like, conserved site
      IPR000203 GPS motif
      IPR003112 Olfactomedin-like domain
      IPR050605 Olfactomedin-like domain-containing protein
    • GlyGen
      Q8JZZ7 7 sites, 11 N-linked glycans (5 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 13
      Primer pair 3
      Other 1
      Antibodies 1

      Microarray probesets 11
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 12
      Gene Ontology 7
      Phenotypes 25
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:388124 King A, et al., Endothelial Adgrl2 Expression and Alternative Splicing Controls the Cerebrovasculature. J Neurosci. 2026 Apr 22;46(16)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory