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Frs3 Gene Detail
Summary
  • Symbol
    Frs3
  • Name
    fibroblast growth factor receptor substrate 3
  • Synonyms
    4930417B13Rik, Frs2beta, MGC:25496, SNT2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2135965
    NCBI Gene: 107971
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:47999955-48015211 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 23.88 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    32 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2135965
 protein coding gene Chr17:47998532-48015211 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023855
 protein coding gene Chr17:48898844-48914059 (+)
A/J MGP_AJ_G0023815
 protein coding gene Chr17:47641042-47656254 (+)
AKR/J MGP_AKRJ_G0023784
 protein coding gene Chr17:48059188-48074391 (+)
BALB/cJ MGP_BALBcJ_G0023817
 protein coding gene Chr17:47554068-47569315 (+)
C3H/HeJ MGP_C3HHeJ_G0023580
 protein coding gene Chr17:48786678-48801904 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024261
 protein coding gene Chr17:50942875-50958093 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021710
 protein coding gene Chr17:44398522-44414044 (+)
CAST/EiJ MGP_CASTEiJ_G0023062
 protein coding gene Chr17:48898055-48913319 (+)
CBA/J MGP_CBAJ_G0023557
 protein coding gene Chr17:52788983-52804486 (+)
DBA/2J MGP_DBA2J_G0023685
 protein coding gene Chr17:46397005-46412232 (+)
FVB/NJ MGP_FVBNJ_G0023651
 protein coding gene Chr17:46054911-46070122 (+)
LP/J MGP_LPJ_G0023765
 protein coding gene Chr17:49553194-49568456 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023679
 protein coding gene Chr17:52264432-52279663 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024306
 protein coding gene Chr17:48413025-48428256 (+)
PWK/PhJ MGP_PWKPhJ_G0022807
 protein coding gene Chr17:45771346-45787016 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022622
 protein coding gene Chr17:45299047-45314241 (+)
WSB/EiJ MGP_WSBEiJ_G0023127
 protein coding gene Chr17:48992573-49011151 (+)



Homology
more
  • Human Ortholog
    FRS3, fibroblast growth factor receptor substrate 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FRS3, fibroblast growth factor receptor substrate 3
  • Synonyms
    FRS2B, FRS2beta, FRS2-beta, SNT2, SNT-2
  • Links
    NCBI Gene ID: 10817
    neXtProt AC: NX_O43559
    UniProt: O43559

  • Chr Location
    6p21.1; chr6:41770176-41786542 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    11 phenotypes from multigenic genotypes
    10 phenotype references
Mice homozygous for a knock-out allele appear normal and are fertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    780
  • Tissues
    60
  • cDNA Data
    6
  • Literature Summary
    6
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000023266 Ensembl Gene Model | MGI Sequence Detail 15257 C57BL/6J ±  kb
transcript ENSMUST00000113296 Ensembl | MGI Sequence Detail 2144 Not Applicable  
polypeptide ENSMUSP00000108921 Ensembl | MGI Sequence Detail 492 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 9
    cDNA 7
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGI:2146863, MGI:2385322
References
more
  • Summaries
    All 44
    Developmental Gene Expression 6
    Gene Ontology 5
    Phenotypes 10
  • Earliest
    J:69784 McDougall K, et al., Developmental expression patterns of the signaling adapters FRS-2 and FRS-3 during early embryogenesis. Mech Dev. 2001 May;103(1-2):145-8
  • Latest
    J:313934 Takeuchi Y, et al., The membrane-linked adaptor FRS2beta fashions a cytokine-rich inflammatory microenvironment that promotes breast cancer carcinogenesis. Proc Natl Acad Sci U S A. 2021 Oct 26;118(43):e2103658118
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory