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Asic5 Gene Detail
Summary
  • Symbol
    Asic5
  • Name
    acid-sensing ion channel family member 5
  • Synonyms
    Accn5, BLINaC, brain-liver-intestine amiloride-sensitive sodium channel
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929259
    NCBI Gene: 58170
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:81889600-81928540 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 35.97 cM, cytoband E-F1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1443 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929259
 protein coding gene Chr3:81889597-81928540 (+)
129S1/SvImJ ENSMUSG00200018732
 protein coding gene Chr3:78756221-78781193 (+)
A/J ENSMUSG00195011719
 protein coding gene Chr3:78764121-78789109 (+)
AKR/J ENSMUSG00220001244
 protein coding gene Chr3:78720245-78745229 (+)
BALB/cJ ENSMUSG00180001871
 protein coding gene Chr3:78893117-78918100 (+)
C3H/HeJ ENSMUSG00175007004
 protein coding gene Chr3:78690793-78715776 (+)
C57BL/6NJ ENSMUSG00215001960
 protein coding gene Chr3:79143059-79168623 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025096
 protein coding gene Chr3:74837125-74876206 (+)
CAST/EiJ ENSTCUG00005001524
 protein coding gene Chr3:78230552-78256144 (+)
CBA/J ENSMUSG00210025175
 protein coding gene Chr3:78821325-78846310 (+)
DBA/2J ENSMUSG00185012602
 protein coding gene Chr3:78977799-79002784 (+)
FVB/NJ ENSMUSG00205006214
 protein coding gene Chr3:77748008-77773577 (+)
JF1/MsJ ENSUMUG00000001070
 protein coding gene Chr3:78499433-78524879 (+)
LP/J ENSMUSG00230009288
 protein coding gene Chr3:80964824-80989793 (+)
NOD/ShiLtJ ENSMUSG00190002645
 protein coding gene Chr3:79216267-79241829 (+)
NZO/HlLtJ ENSMUSG00225005274
 protein coding gene Chr3:83695725-83721289 (+)
PWK/PhJ ENSLUMG00010006170
 protein coding gene Chr3:78568940-78594362 (+)
SPRET/EiJ ENSMSPG00010016896
 protein coding gene Chr3:79373892-79396867 (+)
WSB/EiJ ENSIUOG00005002926
 protein coding gene Chr3:79188981-79219824 (+)



Homology
more
  • Human Ortholog
    ASIC5, acid sensing ion channel subunit family member 5
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ASIC5, acid sensing ion channel subunit family member 5
  • Synonyms
    ACCN5, BASIC, HINAC, INAC
  • Links
    NCBI Gene ID: 51802
    UniProt: Q9NY37

  • Chr Location
    4q32.1; chr4:155829729-155866277 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    13 phenotype references
  • All Mutations and Alleles
    12
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    3
  • Radiation induced
    1
  • Targeted
    7
  • Genomic Mutations
    2 involving Asic5
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
    35 strains or lines available
Mice homozygous for a knock-out allele are viable and fertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    603
  • Tissues
    5
  • cDNA Data
    3
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 58170 NCBI Gene Model | MGI Sequence Detail 38941 C57BL/6J ±  kb
transcript NM_021370 RefSeq | MGI Sequence Detail 1657 C57BL/6  
polypeptide Q9R0Y1 UniProt | EBI | MGI Sequence Detail 495 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 4
    Genomic 1
    cDNA 3

    Microarray probesets 3
References
more
  • Summaries
    All 41
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 13
    Phenotypes 13
  • Earliest
    J:66332 Sakai H, et al., Cloning and functional expression of a novel degenerin-like Na+ channel gene in mammals. J Physiol. 1999 Sep 1;519 Pt 2:323-33
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory