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Rassf1 Gene Detail
Summary
  • Symbol
    Rassf1
  • Name
    Ras association (RalGDS/AF-6) domain family member 1
  • Synonyms
    123F protein, NORE2A, Rassf1A, Rassf1B, Rassf1C, RDA32, REH3P21
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928386
    NCBI Gene: 56289
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:107428752-107439460 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 58.12 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    73 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1928386
 protein coding gene Chr9:107428752-107439466 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035257
 protein coding gene Chr9:109427027-109437669 (+)
A/J MGP_AJ_G0035236
 protein coding gene Chr9:105448522-105459217 (+)
AKR/J MGP_AKRJ_G0035168
 protein coding gene Chr9:108080652-108091347 (+)
BALB/cJ MGP_BALBcJ_G0035230
 protein coding gene Chr9:105117789-105128484 (+)
C3H/HeJ MGP_C3HHeJ_G0034940
 protein coding gene Chr9:108479812-108490507 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035750
 protein coding gene Chr9:112418552-112429264 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032648
 protein coding gene Chr9:102877431-102888756 (+)
CAST/EiJ MGP_CASTEiJ_G0034251
 protein coding gene Chr9:108412464-108423180 (+)
CBA/J MGP_CBAJ_G0034908
 protein coding gene Chr9:116391613-116403105 (+)
DBA/2J MGP_DBA2J_G0035069
 protein coding gene Chr9:104902228-104912940 (+)
FVB/NJ MGP_FVBNJ_G0035017
 protein coding gene Chr9:103667070-103677765 (+)
LP/J MGP_LPJ_G0035145
 protein coding gene Chr9:109633178-109643873 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035056
 protein coding gene Chr9:118004668-118015363 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035771
 protein coding gene Chr9:108352116-108362811 (+)
PWK/PhJ MGP_PWKPhJ_G0033958
 protein coding gene Chr9:105222375-105233094 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033793
 protein coding gene Chr9:108408152-108418846 (+)
WSB/EiJ MGP_WSBEiJ_G0034372
 protein coding gene Chr9:108235252-108245947 (+)



Homology
more
  • Human Ortholog
    RASSF1, Ras association domain family member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RASSF1, Ras association domain family member 1
  • Synonyms
    123F2, NORE2A, RASSF1A, RDA32, REH3P21
  • Links
    NCBI Gene ID: 11186
    neXtProt AC: NX_Q9NS23
    UniProt: Q9NS23

  • Chr Location
    3p21.31; chr3:50329782-50340980 (-)  GRCh38
Human Diseases
more
  • Diseases
    9 with human RASSF1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 3 alleles in 5 genetic backgrounds
    6 phenotypes from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous and heterozygous null mice display increased tumor incidence, especially of lung adenomas and lymphomas, and increased sensitivity to chemically induced tumors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    711
  • Tissues
    3
  • cDNA Data
    9
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56289 NCBI Gene Model | MGI Sequence Detail 10709 C57BL/6J ±  kb
    transcript NM_001411798 RefSeq | MGI Sequence Detail 3494 C57BL/6  
    polypeptide Q99MK9 UniProt | EBI | MGI Sequence Detail 340 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000013763 Ras association domain-containing protein 1
      (term hierarchy)
    • InterPro Domains
      IPR046349 C1-like domain superfamily
      IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
      IPR000159 Ras-associating domain
      IPR033614 Ras association domain-containing protein 1-6
      IPR033600 Ras association domain-containing protein 1, RA domain
      IPR011524 SARAH domain
      IPR029071 Ubiquitin-like domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 10
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2143239
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 4
      Gene Ontology 8
      Phenotypes 28
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:281342 Francisco J, et al., The tumor suppressor RASSF1A modulates inflammation and injury in the reperfused murine myocardium. J Biol Chem. 2019 Aug 30;294(35):13131-13144
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory