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Pbrm1 Gene Detail
Summary
  • Symbol
    Pbrm1
  • Name
    polybromo 1
  • Synonyms
    2310032M22Rik, 2610016F04Rik, BAF180, Pb1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923998
    NCBI Gene: 66923
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:30741095-30843549 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 19.09 cM, cytoband B
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1834 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923998
 protein coding gene Chr14:30741095-30843549 (+)
129S1/SvImJ ENSMUSG00200036972
 protein coding gene Chr14:22562802-22665243 (+)
A/J ENSMUSG00195013365
 protein coding gene Chr14:23638306-23740762 (+)
AKR/J ENSMUSG00220030286
 protein coding gene Chr14:22750669-22853126 (+)
BALB/cJ ENSMUSG00180022912
 protein coding gene Chr14:22726890-22829347 (+)
C3H/HeJ ENSMUSG00175039166
 protein coding gene Chr14:22794201-22896654 (+)
C57BL/6NJ ENSMUSG00215024898
 protein coding gene Chr14:23032588-23135043 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019064
 protein coding gene Chr14:23332406-23437500 (+)
CAST/EiJ ENSTCUG00005022614
 protein coding gene Chr14:22882161-22984703 (+)
CBA/J ENSMUSG00210039322
 protein coding gene Chr14:23037114-23139568 (+)
DBA/2J ENSMUSG00185035879
 protein coding gene Chr14:27306572-27409013 (+)
FVB/NJ ENSMUSG00205018608
 protein coding gene Chr14:22896165-22998627 (+)
JF1/MsJ ENSUMUG00000037627
 protein coding gene Chr14:34565047-34667812 (+)
LP/J ENSMUSG00230032293
 protein coding gene Chr14:34586815-34689259 (+)
NOD/ShiLtJ ENSMUSG00190016103
 protein coding gene Chr14:23050711-23153160 (+)
NZO/HlLtJ ENSMUSG00225035912
 protein coding gene Chr14:28925403-29027853 (+)
PWK/PhJ ENSLUMG00010020344
 protein coding gene Chr14:11160429-11263251 (+)
SPRET/EiJ ENSMSPG00010038702
 protein coding gene Chr14:24697755-24805681 (+)
WSB/EiJ ENSIUOG00005011802
 protein coding gene Chr14:22855307-22957754 (+)



Homology
more
  • Human Ortholog
    PBRM1, polybromo 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PBRM1, polybromo 1
  • Synonyms
    BAF180, PB1, RCC, SMARCH1
  • Links
    NCBI Gene ID: 55193
    UniProt: Q86U86

  • Chr Location
    3p21.1; chr3:52544735-52685966 (-)  GRCh38
Human Diseases
more
  • Diseases
    4 with human PBRM1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 3 alleles in 3 genetic backgrounds
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality with hypoplastic cardiac ventricular chambers and malformation of the placenta.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    24
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    686
  • Tissues
    62
  • cDNA Data
    225
  • Literature Summary
    26
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 66923 NCBI Gene Model | MGI Sequence Detail 102455 C57BL/6J ±  kb
    transcript NM_001359854 RefSeq | MGI Sequence Detail 8155 C57BL/6  
    polypeptide Q8BSQ9 UniProt | EBI | MGI Sequence Detail 1634 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 232
      cDNA 225
      Primer pair 6
      Other 1
      Antibodies 2

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGI:1914173, MGI:2145667
    References
    more
    • Summaries
      All 112
      Developmental Gene Expression 26
      Gene Ontology 24
      Phenotypes 32
    • Earliest
      J:35263 Wang W, et al., Diversity and specialization of mammalian SWI/SNF complexes. Genes Dev. 1996 Sep 1;10(17):2117-30
    • Latest
      J:378799 Li J, et al., Synovial sarcoma reprograms transcription by GBAF activation of polycomb targets and loss of CBAF enhancers. Nat Commun. 2025 Dec 21;17(1):1081
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory