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Rnf139 Gene Detail
Summary
  • Symbol
    Rnf139
  • Name
    ring finger protein 139
  • Synonyms
    4930555P18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923091
    NCBI Gene: 75841
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:58760975-58774239 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 25.09 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    260 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923091
 protein coding gene Chr15:58760975-58778906 (+)
129S1/SvImJ ENSMUSG00200028344
 protein coding gene Chr15:55747406-55760575 (+)
A/J ENSMUSG00195006130
 protein coding gene Chr15:55809816-55822977 (+)
AKR/J ENSMUSG00220020395
 protein coding gene Chr15:55783957-55797118 (+)
BALB/cJ ENSMUSG00180008712
 protein coding gene Chr15:55744544-55757705 (+)
C3H/HeJ ENSMUSG00175004658
 protein coding gene Chr15:55995862-56009023 (+)
C57BL/6NJ ENSMUSG00215007927
 protein coding gene Chr15:55727124-55740285 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019821
 protein coding gene Chr15:52914770-52930043 (+)
CAST/EiJ ENSTCUG00005006726
 protein coding gene Chr15:55623615-55637805 (+)
CBA/J ENSMUSG00210007044
 protein coding gene Chr15:55823989-55837150 (+)
DBA/2J ENSMUSG00185025682
 protein coding gene Chr15:55785384-55798545 (+)
FVB/NJ ENSMUSG00205006578
 protein coding gene Chr15:55570941-55584121 (+)
JF1/MsJ ENSUMUG00000015628
 protein coding gene Chr15:55586506-55600723 (+)
LP/J ENSMUSG00230007880
 protein coding gene Chr15:59090931-59104100 (+)
NOD/ShiLtJ ENSMUSG00190016767
 protein coding gene Chr15:55805161-55818322 (+)
NZO/HlLtJ ENSMUSG00225028454
 protein coding gene Chr15:59420072-59433233 (+)
PWK/PhJ ENSLUMG00010027695
 protein coding gene Chr15:55867478-55881679 (+)
SPRET/EiJ ENSMSPG00010023313
 protein coding gene Chr15:57071461-57085656 (+)
WSB/EiJ ENSIUOG00005006111
 protein coding gene Chr15:55841927-55855125 (+)



Homology
more
  • Human Ortholog
    RNF139, ring finger protein 139
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RNF139, ring finger protein 139
  • Synonyms
    HRCA1, RCA1, TRC8
  • Links
    NCBI Gene ID: 11236
    UniProt: Q8WU17

  • Chr Location
    8q24.13; chr8:124474866-124488618 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human RNF139 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased diet-induced liver apoptosis, inflammation and fibrosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    627
  • Tissues
    30
  • cDNA Data
    8
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 75841 NCBI Gene Model | MGI Sequence Detail 13265 C57BL/6J ±  kb
    transcript NM_175226 RefSeq | MGI Sequence Detail 4348 C57BL/6  
    polypeptide Q7TMV1 UniProt | EBI | MGI Sequence Detail 668 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 8

      Microarray probesets 4
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 8
      Phenotypes 28
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory