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Pik3cb Gene Detail
Summary
  • Symbol
    Pik3cb
  • Name
    phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
  • Synonyms
    1110001J02Rik, p110beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922019
    NCBI Gene: 74769
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:98920455-99022264 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 51.41 cM, cytoband E4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2907 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922019
 protein coding gene Chr9:98918707-99022674 (-)
129S1/SvImJ ENSMUSG00200016317
 protein coding gene Chr9:96039124-96143079 (-)
A/J ENSMUSG00195015225
 protein coding gene Chr9:95280981-95384968 (-)
AKR/J ENSMUSG00220034324
 protein coding gene Chr9:95650530-95754683 (-)
BALB/cJ ENSMUSG00180022613
 protein coding gene Chr9:95600547-95704532 (-)
C3H/HeJ ENSMUSG00175012294
 protein coding gene Chr9:95943396-96047369 (-)
C57BL/6NJ ENSMUSG00215016266
 protein coding gene Chr9:95936675-96040631 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032558
 protein coding gene Chr9:94589586-94695767 (-)
CAST/EiJ ENSTCUG00005012984
 protein coding gene Chr9:95767120-95871131 (-)
CBA/J ENSMUSG00210014539
 protein coding gene Chr9:95781679-95885657 (-)
DBA/2J ENSMUSG00185010592
 protein coding gene Chr9:95957712-96062133 (-)
FVB/NJ ENSMUSG00205013817
 protein coding gene Chr9:95974214-96078191 (-)
JF1/MsJ ENSUMUG00000018197
 protein coding gene Chr9:95746972-95852456 (-)
LP/J ENSMUSG00230020143
 protein coding gene Chr9:96125699-96230125 (-)
NOD/ShiLtJ ENSMUSG00190032437
 protein coding gene Chr9:95603236-95707275 (-)
NZO/HlLtJ ENSMUSG00225020167
 protein coding gene Chr9:96306141-96411450 (-)
PWK/PhJ ENSLUMG00010025326
 protein coding gene Chr9:95726468-95831145 (-)
SPRET/EiJ ENSMSPG00010003363
 protein coding gene Chr9:97539098-97642812 (-)
WSB/EiJ ENSIUOG00005023537
 protein coding gene Chr9:95034958-95138911 (-)



Homology
more
  • Human Ortholog
    PIK3CB, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PIK3CB, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
  • Synonyms
    P110BETA, PI3K, PI3KBETA, PIK3C1
  • Links
    NCBI Gene ID: 5291
    UniProt: P42338

  • Chr Location
    3q22.3; chr3:138652336-138834957 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human PIK3CB associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    51 phenotypes from 9 alleles in 13 genetic backgrounds
    9 phenotypes from multigenic genotypes
    1 images
    74 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit 30% fetal lethality, decreased size at birth and postnatally, abnormal glucose homeostasis, and dyslipidemia. Mice homozygous for a different knock-out allele die prior to E8.5
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    87
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    781
  • Tissues
    131
  • cDNA Data
    44
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 74769 NCBI Gene Model | MGI Sequence Detail 101810 C57BL/6J ±  kb
    transcript NM_029094 RefSeq | MGI Sequence Detail 4854 C57BL/6  
    polypeptide Q8BTI9 UniProt | EBI | MGI Sequence Detail 1064 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000012720 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
      (term hierarchy)
    • PDB
      2Y3A, 4BFR
    • EC
      2.7.1.153, 2.7.11.1
    • InterPro Domains
      IPR016024 Armadillo-type fold
      IPR035892 C2 domain superfamily
      IPR002420 C2 phosphatidylinositol 3-kinase-type domain
      IPR015433 Phosphatidylinositol 3-/4-kinase
      IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
      IPR036940 Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily
      IPR018936 Phosphatidylinositol 3-/4-kinase, conserved site
      IPR003113 Phosphatidylinositol 3-kinase, adaptor-binding domain
      IPR037702 Phosphatidylinositol 3-kinase beta, catalytic domain
      IPR000341 Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
      IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
      IPR042236 Phosphoinositide 3-kinase, accessory (PIK) domain superfamily
      IPR011009 Protein kinase-like domain superfamily
      IPR029071 Ubiquitin-like domain superfamily
    • GlyGen
      Q8BTI9 2 sites, 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 47
      cDNA 44
      Primer pair 3
      Antibodies 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2143049
    References
    more
    • Summaries
      All 162
      Developmental Gene Expression 14
      Gene Ontology 18
      Phenotypes 74
    • Earliest
      J:214 ALLEN SL, H-2f, a tenth allele at the histocompatibility-2 locus in the mouse as determined by tumor transplantation. Cancer Res. 1955 Jun;15(5):315-9
    • Latest
      J:375476 Conduit SE, et al., Novel role for PI3Kbeta in placental function through regulation of system A amino acid transporter expression, associated with embryonic lethality. Cell Mol Life Sci. 2025 Nov 19;82(1):413
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory