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Acot12 Gene Detail
Summary
  • Symbol
    Acot12
  • Name
    acyl-CoA thioesterase 12
  • Synonyms
    1300004O04Rik, 4930449F15Rik, Cach
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921406
    NCBI Gene: 74156
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:91889635-91934271 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 47.43 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1451 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921406
 protein coding gene Chr13:91889631-91934271 (+)
129S1/SvImJ ENSMUSG00200008663
 protein coding gene Chr13:86382805-86427426 (+)
A/J ENSMUSG00195023817
 protein coding gene Chr13:86891555-86936147 (+)
AKR/J ENSMUSG00220013666
 protein coding gene Chr13:85386812-85431458 (+)
BALB/cJ ENSMUSG00180015279
 protein coding gene Chr13:87425109-87469752 (+)
C3H/HeJ ENSMUSG00175022686
 protein coding gene Chr13:87599667-87644230 (+)
C57BL/6NJ ENSMUSG00215002938
 protein coding gene Chr13:87486316-87530961 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018763
 protein coding gene Chr13:85551543-85590817 (+)
CAST/EiJ ENSTCUG00005008917
 protein coding gene Chr13:86703273-86757590 (+)
CBA/J ENSMUSG00210024235
 protein coding gene Chr13:86879472-86924037 (+)
DBA/2J ENSMUSG00185009952
 protein coding gene Chr13:90565461-90610032 (+)
FVB/NJ ENSMUSG00205007689
 protein coding gene Chr13:86362602-86407169 (+)
JF1/MsJ ENSUMUG00000020945
 protein coding gene Chr13:90298527-90342633 (+)
LP/J ENSMUSG00230004127
 protein coding gene Chr13:100583590-100628157 (+)
NOD/ShiLtJ ENSMUSG00190018140
 protein coding gene Chr13:87271820-87316408 (+)
NZO/HlLtJ ENSMUSG00225032531
 protein coding gene Chr13:93113916-93158483 (+)
PWK/PhJ ENSLUMG00010011362
 protein coding gene Chr13:86415474-86469983 (+)
SPRET/EiJ ENSMSPG00010006438
 protein coding gene Chr13:87605757-87655545 (+)
WSB/EiJ ENSIUOG00005030127
 protein coding gene Chr13:86290417-86335103 (+)



Homology
more
  • Human Ortholog
    ACOT12, acyl-CoA thioesterase 12
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ACOT12, acyl-CoA thioesterase 12
  • Synonyms
    Cach, CACH-1, STARD15, THEAL
  • Links
    NCBI Gene ID: 134526
    UniProt: Q8WYK0

  • Chr Location
    5q14.1; chr5:81308609-81394191 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 3 alleles in 3 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show accelerated liver tumor formation in DEN/CCl4-induced and diet-induced hepatocarcinogenesis. Mice homozygous for a different null allele exhibit impaired glucose tolerance, insulin resistance, accumulation of hepatic fat and acetyl-CoA, and increased de novo lipogenesis and cholesterol biosynthesis in the liver, independent of a high-fat diet.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    691
  • Tissues
    94
  • cDNA Data
    13
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 74156 NCBI Gene Model | MGI Sequence Detail 44637 C57BL/6J ±  kb
    transcript NM_028790 RefSeq | MGI Sequence Detail 3058 C57BL/6  
    polypeptide Q9DBK0 UniProt | EBI | MGI Sequence Detail 556 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      Genomic 1
      cDNA 13

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1922149, MGI:2145388
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 1
      Gene Ontology 12
      Phenotypes 16
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory