Acot12 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Acot12
acyl-CoA thioesterase 12
MGI:1921406

25 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Acot12^{em1(IMPC)Hmgu}/Acot12^{em1(IMPC)Hmgu} C57BL/6NCrl-Acot12^{em1(IMPC)Hmgu}/Ieg	abnormal vocalization	J:211773
	decreased cardiac muscle contractility	J:211773
	dilated heart left ventricle	J:211773
Acot12^em1Ejj/Acot12^em1Ejj C57BL/6N-Acot12^em1Ejj	abnormal enzyme/coenzyme level	J:331239
	abnormal hepatocyte morphology	J:331239
	abnormal liver morphology	J:331239
	abnormal vesicle-mediated transport	J:331239
	enlarged liver	J:331239
	impaired glucose tolerance	J:331239
	increased body weight	J:331239
	increased lipogenesis	J:331239
	increased liver cholesterol level	J:331239
	increased liver free fatty acids level	J:331239
	increased liver triglyceride level	J:331239
	increased liver weight	J:331239
	increased susceptibility to hepatic steatosis	J:331239
	insulin resistance	J:331239
Acot12^em1Holi/Acot12^em1Holi involves: C57BL/6J * C57BL/6N	abnormal ion homeostasis	J:335836
	abnormal phospholipid level	J:335836
	increased circulating cholesterol level	J:335836
	increased circulating phospholipid level	J:335836
	increased hepatocellular carcinoma incidence	J:335836
	increased incidence of tumors by chemical induction	J:335836
	increased liver cholesterol level	J:335836
	increased liver triglyceride level	J:335836
	increased tumor growth/size	J:335836
	liver fibrosis	J:335836

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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