Acot12^em1Ejj
Endonuclease-mediated Allele Detail

Summary

• Symbol: Acot12^em1Ejj
• Name: acyl-CoA thioesterase 12; endonuclease-mediated mutation 1, Eun-Jung Jin
• MGI ID: MGI:7485922
• Synonyms: Acot12^-
• Gene: Acot12 Location: Chr13:91889635-91934271 bp, + strand Genetic Position: Chr13, 47.43 cM
• Alliance: Acot12^em1Ejj page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A 14 bp deletion was generated in exon 1 of the gene, resulting in a frameshift. Immunoblotting and immunostaining analyses confirmed the absence of protein expression in the liver of homozygous mutant mice. (J:331239)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Acot12 Mutation: 37 strains or lines available

References

• Original: J:331239 Park S, et al., Loss of Acot12 contributes to NAFLD independent of lipolysis of adipose tissue. Exp Mol Med. 2021 Jul;53(7):1159-1169
• All: 3 reference(s)