Chit1 MGI Mouse Gene Detail - MGI:1919134

Symbol

Chit1
Name

chitinase 1
Synonyms

2300002L19Rik

Feature Type

protein coding gene
IDs

MGI:1919134
NCBI Gene: 71884
Alliance

genome feature page
Transcription Start Sites

1 TSS

Sequence Map

Chr1:134038980-134079278 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 58.12 cM, cytoband E4
Mapping Data

2 experiments

SNPs within 2kb

1277 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919134	protein coding gene	Chr1:134038980-134079279 (+)
129S1/SvImJ	ENSMUSG00200008379	protein coding gene	Chr1:131642370-131677501 (+)
A/J	ENSMUSG00195038158	protein coding gene	Chr1:130717630-130757933 (+)
AKR/J	ENSMUSG00220045482	protein coding gene	Chr1:130587035-130622187 (+)
BALB/cJ	ENSMUSG00180038079	protein coding gene	Chr1:131265741-131306043 (+)
C3H/HeJ	ENSMUSG00175038591	protein coding gene	Chr1:130961912-131002217 (+)
C57BL/6NJ	ENSMUSG00215043748	protein coding gene	Chr1:130967400-131007707 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014613	protein coding gene	Chr1:125719361-125755332 (+)
CAST/EiJ	ENSTCUG00005033938	protein coding gene	Chr1:129879479-129916768 (+)
CBA/J	ENSMUSG00210026406	protein coding gene	Chr1:130891036-130928219 (+)
DBA/2J	ENSMUSG00185028444	protein coding gene	Chr1:135253800-135288956 (+)
FVB/NJ	ENSMUSG00205042624	protein coding gene	Chr1:130219065-130254222 (+)
JF1/MsJ	ENSUMUG00000019848	protein coding gene	Chr1:134402486-134445179 (+)
LP/J	ENSMUSG00230036477	protein coding gene	Chr1:134800636-134840934 (+)
NOD/ShiLtJ	ENSMUSG00190026813	protein coding gene	Chr1:130905179-130942345 (+)
NZO/HlLtJ	ENSMUSG00225018599	protein coding gene	Chr1:138562424-138597862 (+)
PWK/PhJ	ENSLUMG00010022338	protein coding gene	Chr1:130032856-130071082 (+)
SPRET/EiJ	ENSMSPG00010041578	protein coding gene	Chr1:132831269-132868693 (+)
WSB/EiJ	ENSIUOG00005044762	protein coding gene	Chr1:130644666-130682087 (+)

Human Ortholog

CHIT1, chitinase 1

Vertebrate Orthologs

7

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CHIT1, chitinase 1
Synonyms

CHI3, CHIT, CHITD
Links

HGNC:1936

NCBI Gene ID: 1118

UniProt: Q13231
Chr Location

1q32.1; chr1:203212827-203273641 (-) GRCh38

MGI Vertebrate Homology

Chit1 stringent orthology
1 human;1 mouse;1 rat;5 zebrafish
HCOP

vertebrate homology predictions: CHIT1
Gene Tree

Chit1

Diseases

14 with human CHIT1 associations

				Human Disease	Mouse Models
				allergic asthma IDs allergic asthma DOID:9415 DOID:9416 DOID:9417 ICD10CM:J45 ICD9CM:493.0 UMLS_CUI:C0155877
				allergic disease IDs allergic disease DOID:1205 ICD10CM:T78.40 MESH:D006967 NCI:C3114 UMLS_CUI:C0020517
				asbestosis IDs asbestosis DOID:10320 ICD10CM:J61 ICD9CM:501 MESH:D001195 NCI:C84573 UMLS_CUI:C0003949
				aspergillosis IDs aspergillosis DOID:13564 ICD10CM:B44 ICD9CM:117.3 MESH:D001228 NCI:C2886 UMLS_CUI:C0004030
				asthma IDs asthma DOID:2841 DOID:12703 DOID:13829 DOID:13830 DOID:2840 DOID:5783 ICD10CM:J45 ICD9CM:493 ICD9CM:493.9 KEGG:05310 MESH:D001249 NCI:C28397 OMIM:600807 UMLS_CUI:C0004096
				bronchiectasis IDs bronchiectasis DOID:9563 DOID:11046 DOID:11047 DOID:9571 ICD10CM:J47 ICD9CM:494 MESH:D001987 NCI:C84475 OMIM:PS211400 ORDO:60033 UMLS_CUI:C0006267
				candidiasis IDs candidiasis DOID:1508 DOID:1507 ICD10CM:B37 ICD9CM:112 ICD9CM:112.9 ICD9CM_2006:112.5 MESH:D002177 NCI:C26711 UMLS_CUI:C0006840
				chronic obstructive pulmonary disease IDs chronic obstructive pulmonary disease DOID:3083 DOID:11500 DOID:6144 EFO:0000341 ICD10CM:J44.9 MESH:D029424 NCI:C3199 OMIM:606963 UMLS_CUI:C0024117
				cystic fibrosis IDs cystic fibrosis DOID:1485 DOID:12447 DOID:13383 DOID:14395 DOID:1484 ICD10CM:E84 ICD9CM:277.0 MESH:D003550 NCI:C2975 OMIM:219700 ORDO:586 UMLS_CUI:C0010674
				Gaucher's disease IDs Gaucher's disease DOID:1926 ICD10CM:E75.22 MESH:D005776 NCI:C61268 ORDO:355 UMLS_CUI:C0017205
				pulmonary fibrosis IDs pulmonary fibrosis DOID:3770 MESH:D011658 NCI:C26869 UMLS_CUI:C0034069
				pulmonary tuberculosis IDs pulmonary tuberculosis DOID:2957 ICD10CM:A15 ICD9CM:011 ICD9CM:011.9 ICD9CM:011.90 MESH:D014397 NCI:C26899 UMLS_CUI:C0041327
				silicosis IDs silicosis DOID:10325 DOID:14007 ICD10CM:J62.8 ICD9CM:502 MESH:D012829 NCI:C3369 UMLS_CUI:C0037116
				tuberculosis IDs tuberculosis DOID:399 DOID:10096 DOID:12688 DOID:12691 DOID:415 DOID:9901 DOID:9902 MESH:D014375 UMLS_CUI:C0041295

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
1 phenotype from multigenic genotypes
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

2
Endonuclease-mediated

5
Gene trapped

1
Radiation induced

1
Targeted

5
Genomic Mutations

3 involving Chit1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

32 strains or lines available

Mice homozygous for a knock-out allele exhibit reduced pulmonary fibrosis induced by bleomycin or IL13 expression.

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All GO Annotations

25
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

694
Tissues

95
cDNA Data

9
Literature Summary

2

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase chit1

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All Sequences

46
RefSeq

12
UniProt

2
CCDS

CCDS15304.1, CCDS69943.1

Ensembl

ENSMUSG00000026450 (Evidence)
NCBI Gene

71884

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026450	Ensembl Gene Model \| MGI Sequence Detail	40299	C57BL/6J	± kb
transcript	ENSMUST00000159963	Ensembl \| MGI Sequence Detail	1815	Not Applicable
polypeptide	ENSMUSP00000123979	Ensembl \| MGI Sequence Detail	464	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000005426 chitotriosidase-1

(term hierarchy)
EC

3.2.1.14
InterPro Domains

IPR011583 Chitinase II/V-like, catalytic domain

IPR029070 Chitinase insertion domain superfamily

IPR002557 Chitin binding domain

IPR036508 Chitin binding domain superfamily

IPR001223 Glycoside hydrolase family 18, catalytic domain

IPR017853 Glycoside hydrolase superfamily

IPR050314 Glycosyl hydrolase family 18

IPR001579 Glycosyl hydrolase family 18, active site

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All nucleic 11

cDNA 9

Primer pair 2

Microarray probesets 3

Summaries

All 50

Developmental Gene Expression 2

Gene Ontology 9

Phenotypes 16
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:339269 Sklepkiewicz P, et al., Inhibition of CHIT1 as a novel therapeutic approach in idiopathic pulmonary fibrosis. Eur J Pharmacol. 2022 Mar 15;919:174792

TSS for Chit1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr8857	Chr1:134038971-134038986 (+)	-1 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24