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Crtc3 Gene Detail
Summary
  • Symbol
    Crtc3
  • Name
    CREB regulated transcription coactivator 3
  • Synonyms
    2610312F20Rik, 6332415K15Rik, MGC:19083
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917711
    NCBI Gene: 70461
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:80236375-80338625 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 45.65 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    816 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917711
 protein coding gene Chr7:80236375-80339443 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032417
 protein coding gene Chr7:82565931-82676365 (-)
A/J MGP_AJ_G0032396
 protein coding gene Chr7:80637358-80741774 (-)
AKR/J MGP_AKRJ_G0032332
 protein coding gene Chr7:82399083-82509265 (-)
BALB/cJ MGP_BALBcJ_G0032408
 protein coding gene Chr7:80310903-80415378 (-)
C3H/HeJ MGP_C3HHeJ_G0032121
 protein coding gene Chr7:83029082-83135911 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032900
 protein coding gene Chr7:85806443-85912157 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029908
 protein coding gene Chr7:83155117-83259569 (-)
CAST/EiJ MGP_CASTEiJ_G0031449
 protein coding gene Chr7:73923336-74033438 (-)
CBA/J MGP_CBAJ_G0032087
 protein coding gene Chr7:88657974-88768434 (-)
DBA/2J MGP_DBA2J_G0032242
 protein coding gene Chr7:79192486-79296465 (-)
FVB/NJ MGP_FVBNJ_G0032197
 protein coding gene Chr7:79116319-79222186 (-)
LP/J MGP_LPJ_G0032323
 protein coding gene Chr7:83805013-83915115 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032234
 protein coding gene Chr7:88800953-88909114 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032918
 protein coding gene Chr7:81821107-81931340 (-)
PWK/PhJ MGP_PWKPhJ_G0031169
 protein coding gene Chr7:72386341-72491741 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031010
 protein coding gene Chr7:68826971-68932268 (-)
WSB/EiJ MGP_WSBEiJ_G0031567
 protein coding gene Chr7:82178790-82291096 (-)



Homology
more
  • Human Ortholog
    CRTC3, CREB regulated transcription coactivator 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CRTC3, CREB regulated transcription coactivator 3
  • Synonyms
    TORC3, TORC-3
  • Links
    NCBI Gene ID: 64784
    neXtProt AC: NX_Q6UUV7
    UniProt: Q6UUV7

  • Chr Location
    15q26.1; chr15:90529923-90645345 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 2 alleles in 2 genetic backgrounds
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display resistance to diet-induced obesity, increased energy expenditure, decreased white adipose tissue mass, increased brown adipose cell numbers, and increased core temperature.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    44
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030527 Ensembl Gene Model | MGI Sequence Detail 102251 C57BL/6J ±  kb
    transcript ENSMUST00000122255 Ensembl | MGI Sequence Detail 5115 Not Applicable  
    polypeptide ENSMUSP00000113540 Ensembl | MGI Sequence Detail 619 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000005903 CREB-regulated transcription coactivator 3
      (term hierarchy)
    • InterPro Domains
      IPR024786 CREB-regulated transcription coactivator
      IPR024785 Transducer of regulated CREB activity, C-terminal
      IPR024784 Transducer of regulated CREB activity, middle domain
      IPR024783 Transducer of regulated CREB activity, N-terminal
    Molecular
    Reagents
    less
    • All nucleic 44
      cDNA 44

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2141955, MGI:2444551, MGI:2447777
    References
    more
    • Summaries
      All 57
      Gene Ontology 8
      Phenotypes 27
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:340882 Park JS, et al., Amphiregulin normalizes altered circuit connectivity for social dominance of the CRTC3 knockout mouse. Mol Psychiatry. 2023 Sep 20;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory