Crtc3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Crtc3
CREB regulated transcription coactivator 3
MGI:1917711

21 phenotypes from 2 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Crtc3^{tm1b(KOMP)Wtsi}/Crtc3⁺ C57BL/6N-Crtc3^{tm1b(KOMP)Wtsi}/Ucd	corneal opacity	J:211773
	decreased body length	J:211773
Crtc3^{tm1b(KOMP)Wtsi}/Crtc3^{tm1b(KOMP)Wtsi} C57BL/6N-Crtc3^{tm1b(KOMP)Wtsi}/Ucd	preweaning lethality, incomplete penetrance	J:211773
Crtc3^tm1Mmy/Crtc3⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6	decreased susceptibility to diet-induced obesity	J:167211
Crtc3^tm1Mmy/Crtc3^tm1Mmy involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal brown fat cell morphology	J:167211
	abnormal cell physiology	J:167211
	abnormal glucose homeostasis	J:167211
	abnormal white adipose tissue physiology	J:167211
	decreased brown fat cell lipid droplet size	J:167211
	decreased circulating free fatty acids level	J:167211
	decreased circulating insulin level	J:167211
	decreased circulating leptin level	J:167211
	decreased susceptibility to diet-induced hepatic steatosis	J:167211
	decreased susceptibility to diet-induced obesity	J:167211
	decreased total body fat amount	J:167211
	decreased white fat cell size	J:167211
	increased body temperature	J:167211
	increased brown fat cell number	J:167211
	increased energy expenditure	J:167211
	increased insulin sensitivity	J:167211
	increased muscle cell glucose uptake	J:167211
	increased oxygen consumption	J:167211

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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