Naa10 MGI Mouse Gene Detail - MGI:1915255 - N(alpha)-acetyltransferase 10, NatA catalytic subunit

Symbol

Naa10
Name

N(alpha)-acetyltransferase 10, NatA catalytic subunit
Synonyms

2310039H09Rik, Ard1, Ard1a, Te2

Feature Type

protein coding gene
IDs

MGI:1915255
NCBI Gene: 56292
Alliance

genome feature page
Transcription Start Sites

3 TSS

Sequence Map

ChrX:72960479-72965550 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 37.49 cM
Mapping Data

2 experiments

SNPs within 2kb

181 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915255	protein coding gene	ChrX:72960476-72965550 (-)
129S1/SvImJ	ENSMUSG00200042458	protein coding gene	ChrX:55020043-55026138 (-)
A/J	ENSMUSG00195033948	protein coding gene	ChrX:58696281-58702372 (-)
AKR/J	ENSMUSG00220046049	protein coding gene	ChrX:53998579-54004671 (-)
BALB/cJ	ENSMUSG00180047379	protein coding gene	ChrX:55277013-55283105 (-)
C3H/HeJ	ENSMUSG00175031966	protein coding gene	ChrX:58860669-58866760 (-)
C57BL/6NJ	ENSMUSG00215038718	protein coding gene	ChrX:55360663-55366760 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033166	protein coding gene	ChrX:68924463-68929565 (-)
CAST/EiJ	ENSTCUG00005041475	protein coding gene	ChrX:56778425-56784533 (-)
CBA/J	ENSMUSG00210038514	protein coding gene	ChrX:55541339-55547430 (-)
DBA/2J	ENSMUSG00185033214	protein coding gene	ChrX:67962966-67969056 (-)
FVB/NJ	ENSMUSG00205026296	protein coding gene	ChrX:54842317-54848409 (-)
JF1/MsJ	ENSUMUG00000028640	protein coding gene	ChrX:88703660-88709739 (-)
LP/J	ENSMUSG00230031955	protein coding gene	ChrX:74542179-74548274 (-)
NOD/ShiLtJ	ENSMUSG00190031038	protein coding gene	ChrX:54781323-54787414 (-)
NZO/HlLtJ	ENSMUSG00225047284	protein coding gene	ChrX:79746574-79752669 (-)
PWK/PhJ	ENSLUMG00010039329	protein coding gene	ChrX:54524800-54530884 (-)
SPRET/EiJ	ENSMSPG00010031561	protein coding gene	ChrX:57607260-57613380 (-)
WSB/EiJ	ENSIUOG00005048777	protein coding gene	ChrX:55608674-55614759 (-)

Human Ortholog

NAA10, N-alpha-acetyltransferase 10, NatA catalytic subunit

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NAA10, N-alpha-acetyltransferase 10, NatA catalytic subunit
Synonyms

ARD1, ARD1A, ARD1P, DXS707, hARD1, LZMS, MAA, MCOPS1, NATD, OGDNS, TE2
Links

HGNC:18704

NCBI Gene ID: 8260

UniProt: P41227
Chr Location

Xq28; chrX:153929225-153935080 (-) GRCh38

MGI Vertebrate Homology

Naa10 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NAA10
Gene Tree

Naa10

Diseases

2 with human NAA10 associations

				Human Disease	Mouse Models
				Ogden syndrome IDs Ogden syndrome DOID:0050781 OMIM:300855 ORDO:276432
				syndromic microphthalmia 1 IDs syndromic microphthalmia 1 DOID:0111799 OMIM:309800 ORDO:568 ORDO:85275 UMLS_CUI:C1844948

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

65 phenotypes from 5 alleles in 5 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Endonuclease-mediated

8
Targeted

4
Transgenic

2
Find Mice (IMSR)

11 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit increased bone development with increased osteoblast activity, increased bone density, and increased bone thickness of calvaria. Knockout mice harboring a different null allele exhibit partial embryonic lethality, growth retardation, brain disorders, and maternal effect lethality, along with global DNA hypomethylation and enriched dysregulation of imprinted genes in mouse embryos and embryonic stem cells.

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All GO Annotations

48
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

646
Tissues

8
cDNA Data

101
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase naa10

ZFIN naa10

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All Sequences

75
RefSeq

14
UniProt

10
CCDS

CCDS30217.1, CCDS53102.1, CCDS81139.1

Ensembl

ENSMUSG00000031388 (Evidence)
NCBI Gene

56292

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031388	Ensembl Gene Model \| MGI Sequence Detail	5072	C57BL/6J	± kb
transcript	ENSMUST00000033763	Ensembl \| MGI Sequence Detail	962	Not Applicable
polypeptide	ENSMUSP00000033763	Ensembl \| MGI Sequence Detail	235	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000004198 N-alpha-acetyltransferase 10

(term hierarchy)
EC

2.3.1.255
InterPro Domains

IPR016181 Acyl-CoA N-acyltransferase

IPR000182 GNAT domain

IPR045047 N-acetyltransferase Ard1-like

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All nucleic 107

cDNA 105

Primer pair 2

Antibodies 6

Microarray probesets 3

Summaries

All 53

Developmental Gene Expression 5

Gene Ontology 10

Phenotypes 12
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:349445 Lyon GJ, et al., Evaluating possible maternal effect lethality and genetic background effects in Naa10 knockout mice. PLoS One. 2024;19(5):e0301328

TSS for Naa10:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr163594	ChrX:72965536-72965547 (-)	8 bp
Tssr163593	ChrX:72965523-72965528 (-)	24 bp
Tssr163592	ChrX:72965445-72965522 (-)	66 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24