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Wfdc2 Gene Detail
Summary
  • Symbol
    Wfdc2
  • Name
    WAP four-disulfide core domain 2
  • Synonyms
    1600023A02Rik, HE4, WAP5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914951
    NCBI Gene: 67701
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:164404635-164410430 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 85.20 cM, cytoband H3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    305 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914951
 protein coding gene Chr2:164404333-164410430 (+)
129S1/SvImJ ENSMUSG00200016399
 protein coding gene Chr2:161291369-161297788 (+)
A/J ENSMUSG00195019038
 protein coding gene Chr2:161624227-161630646 (+)
AKR/J ENSMUSG00220013701
 protein coding gene Chr2:160953790-160960213 (+)
BALB/cJ ENSMUSG00180047207
 protein coding gene Chr2:161077971-161084390 (+)
C3H/HeJ ENSMUSG00175045508
 protein coding gene Chr2:161824314-161830740 (+)
C57BL/6NJ ENSMUSG00215022003
 protein coding gene Chr2:161275917-161282342 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024650
 protein coding gene Chr2:156499188-156505325 (+)
CAST/EiJ ENSTCUG00005044847
 protein coding gene Chr2:160195913-160202025 (+)
CBA/J ENSMUSG00210016733
 protein coding gene Chr2:161758622-161765041 (+)
DBA/2J ENSMUSG00185045515
 protein coding gene Chr2:161491508-161497932 (+)
FVB/NJ ENSMUSG00205037956
 protein coding gene Chr2:160512365-160518791 (+)
JF1/MsJ ENSUMUG00000013490
 protein coding gene Chr2:161135794-161142383 (+)
LP/J ENSMUSG00230042275
 protein coding gene Chr2:163052470-163058889 (+)
NOD/ShiLtJ ENSMUSG00190044856
 protein coding gene Chr2:161163452-161169871 (+)
NZO/HlLtJ ENSMUSG00225052119
 protein coding gene Chr2:171053829-171060254 (+)
PWK/PhJ ENSLUMG00010041045
 protein coding gene Chr2:161038713-161045307 (+)
SPRET/EiJ ENSMSPG00010025595
 protein coding gene Chr2:163801481-163804842 (+)
WSB/EiJ ENSIUOG00005045007
 protein coding gene Chr2:160884483-160890908 (+)



Homology
more
  • Human Ortholog
    WFDC2, WAP four-disulfide core domain 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WFDC2, WAP four-disulfide core domain 2
  • Synonyms
    BENP, dJ461P17.6, EDDM4, HE4, WAP5
  • Links
    NCBI Gene ID: 10406
    UniProt: Q14508

  • Chr Location
    20q13.12; chr20:45469386-45481533 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 4 alleles in 4 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout affects lung development, leading to respiratory stress, cyanosis and death within hours after birth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    729
  • Tissues
    116
  • cDNA Data
    72
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67701 NCBI Gene Model | MGI Sequence Detail 5796 C57BL/6J ±  kb
    transcript NM_026323 RefSeq | MGI Sequence Detail 708 C57BL/6  
    polypeptide Q9DAU7 UniProt | EBI | MGI Sequence Detail 174 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 74
      cDNA 72
      Primer pair 2

      Microarray probesets 4
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 12
      Gene Ontology 7
      Phenotypes 16
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:372263 Jasmine, et al., Single cell map of the adult female mouse urethra reveals epithelial and stromal macrophages with distinct functional identities. Mucosal Immunol. 2025 Sep 2;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory