Ergic1 MGI Mouse Gene Detail - MGI:1914708 - endoplasmic reticulum-golgi intermediate compartment 1

Symbol

Ergic1
Name

endoplasmic reticulum-golgi intermediate compartment 1
Synonyms

1200007D18Rik

Feature Type

protein coding gene
IDs

MGI:1914708
NCBI Gene: 67458
Alliance

genome feature page
Transcription Start Sites

11 TSS

Sequence Map

Chr17:26780463-26875908 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 13.34 cM, cytoband B1
Mapping Data

2 experiments

SNPs within 2kb

3126 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914708	protein coding gene	Chr17:26779736-26875908 (+)
129S1/SvImJ	ENSMUSG00200049484	protein coding gene	Chr17:22225726-22321072 (+)
A/J	ENSMUSG00195054289	protein coding gene	Chr17:23246351-23341715 (+)
AKR/J	ENSMUSG00220046279	protein coding gene	Chr17:22289752-22384878 (+)
BALB/cJ	ENSMUSG00180048544	protein coding gene	Chr17:22523811-22619168 (+)
C3H/HeJ	ENSMUSG00175053201	protein coding gene	Chr17:22281990-22377470 (+)
C57BL/6NJ	ENSMUSG00215050858	protein coding gene	Chr17:22290119-22385570 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021282	protein coding gene	Chr17:22411156-22508442 (+)
CAST/EiJ	ENSTCUG00005045429	protein coding gene	Chr17:22885208-22980570 (+)
CBA/J	ENSMUSG00210050448	protein coding gene	Chr17:22120841-22216316 (+)
DBA/2J	ENSMUSG00185053082	protein coding gene	Chr17:24334515-24429867 (+)
FVB/NJ	ENSMUSG00205051129	protein coding gene	Chr17:22593162-22688281 (+)
JF1/MsJ	ENSUMUG00000056467	protein coding gene	Chr17:23788478-23883229 (+)
LP/J	ENSMUSG00230055022	protein coding gene	Chr17:25730233-25825578 (+)
NOD/ShiLtJ	ENSMUSG00190036708	protein coding gene	Chr17:22223394-22318506 (+)
NZO/HlLtJ	ENSMUSG00225051624	protein coding gene	Chr17:27653612-27749097 (+)
PWK/PhJ	ENSLUMG00010052242	protein coding gene	Chr17:21703765-21799325 (+)
SPRET/EiJ	ENSMSPG00010043983	protein coding gene	Chr17:23026620-23121232 (+)
WSB/EiJ	ENSIUOG00005045715	protein coding gene	Chr17:22980370-23075883 (+)

Human Ortholog

ERGIC1, endoplasmic reticulum-golgi intermediate compartment 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ERGIC1, endoplasmic reticulum-golgi intermediate compartment 1
Synonyms

AMC2, AMCN, ERGIC-32, ERGIC32, NET24
Links

HGNC:29205

NCBI Gene ID: 57222

UniProt: Q969X5
Chr Location

5q35.1; chr5:172834251-172952792 (+) GRCh38

MGI Vertebrate Homology

Ergic1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ERGIC1
Gene Tree

Ergic1

Diseases

1 with human ERGIC1 associations

				Human Disease	Mouse Models
				neurogenic-type arthrogryposis multiplex congenita-2 IDs neurogenic-type arthrogryposis multiplex congenita-2 DOID:0090124 MESH:C536614 OMIM:208100 ORDO:1143 UMLS_CUI:C1859721

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

110
Endonuclease-mediated

6
Gene trapped

99
Radiation induced

2
Targeted

3
Genomic Mutations

2 involving Ergic1
Incidental Mutations

Mutagenetix , CvDC
Find Mice (IMSR)

133 strains or lines available

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All GO Annotations

19
GO References

5

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

121

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ergic1

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All Sequences

105
RefSeq

20
UniProt

9
CCDS

CCDS28553.1

Ensembl

ENSMUSG00000001576 (Evidence)
NCBI Gene

67458

			Length	Strain/Species	Flank
genomic	ENSMUSG00000001576	Ensembl Gene Model \| MGI Sequence Detail	95446	C57BL/6J	± kb
transcript	ENSMUST00000167662	Ensembl \| MGI Sequence Detail	2754	Not Applicable
polypeptide	ENSMUSP00000132922	Ensembl \| MGI Sequence Detail	290	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000007174 endoplasmic reticulum-Golgi intermediate compartment protein 1

(term hierarchy)
InterPro Domains

IPR045888 Endoplasmic reticulum vesicle transporter

IPR012936 Endoplasmic reticulum vesicle transporter, C-terminal

IPR039542 Endoplasmic reticulum vesicle transporter, N-terminal
GlyGen

Q9DC16 1 site, 1 N-linked glycan (1 site)

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All nucleic 121

cDNA 121

Microarray probesets 6

Summaries

All 46

Gene Ontology 5

Phenotypes 19
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ergic1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr143248	Chr17:26779692-26779716 (+)	-759 bp
Tssr143249	Chr17:26780435-26780448 (+)	-21 bp
Tssr143250	Chr17:26780453-26780479 (+)	3 bp
Tssr143251	Chr17:26780489-26780566 (+)	65 bp
Tssr143252	Chr17:26790076-26790098 (+)	9,624 bp
Tssr143253	Chr17:26790140-26790147 (+)	9,681 bp
Tssr143256	Chr17:26826805-26826819 (+)	46,349 bp
Tssr143257	Chr17:26840486-26840495 (+)	60,028 bp
Tssr143258	Chr17:26843152-26843162 (+)	62,694 bp
Tssr143259	Chr17:26843172-26843173 (+)	62,710 bp
Tssr143260	Chr17:26874893-26874929 (+)	94,448 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24