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Frmd8 Gene Detail
Summary
  • Symbol
    Frmd8
  • Name
    FERM domain containing 8
  • Synonyms
    1200004M23Rik, 2310035N23Rik, 4931429L16Rik, iTAP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914707
    NCBI Gene: 67457
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:5901002-5925297 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 4.34 cM, cytoband A
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    807 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914707
 protein coding gene Chr19:5899730-5925302 (-)
129S1/SvImJ ENSMUSG00200044939
 protein coding gene Chr19:2662144-2687712 (-)
A/J ENSMUSG00195048548
 protein coding gene Chr19:3057446-3083023 (-)
AKR/J ENSMUSG00220043282
 protein coding gene Chr19:2830578-2856158 (-)
BALB/cJ ENSMUSG00180040543
 protein coding gene Chr19:3432161-3457736 (-)
C3H/HeJ ENSMUSG00175010965
 protein coding gene Chr19:2682353-2707929 (-)
C57BL/6NJ ENSMUSG00215043370
 protein coding gene Chr19:2900448-2926026 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022572
 protein coding gene Chr19:2601066-2627356 (-)
CAST/EiJ ENSTCUG00005039567
 protein coding gene Chr19:2819344-2844636 (-)
CBA/J ENSMUSG00210033478
 protein coding gene Chr19:2685122-2710693 (-)
DBA/2J ENSMUSG00185041909
 protein coding gene Chr19:3061611-3087182 (-)
FVB/NJ ENSMUSG00205045389
 protein coding gene Chr19:3067753-3093289 (-)
JF1/MsJ ENSUMUG00000048983
 protein coding gene Chr19:3037816-3062121 (-)
LP/J ENSMUSG00230052775
 protein coding gene Chr19:3969036-3994608 (-)
NOD/ShiLtJ ENSMUSG00190025821
 protein coding gene Chr19:2591955-2617530 (-)
NZO/HlLtJ ENSMUSG00225024881
 protein coding gene Chr19:7677848-7703419 (-)
PWK/PhJ ENSLUMG00010004975
 protein coding gene Chr19:2803119-2827504 (-)
SPRET/EiJ ENSMSPG00010043865
 protein coding gene Chr19:2791206-2820171 (-)
WSB/EiJ ENSIUOG00005038005
 protein coding gene Chr19:2705312-2730866 (-)



Homology
more
  • Human Ortholog
    FRMD8, FERM domain containing 8
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FRMD8, FERM domain containing 8
  • Synonyms
    FKSG44, iTAP
  • Links
    NCBI Gene ID: 83786
    UniProt: Q9BZ67

  • Chr Location
    11q13.1; chr11:65368026-65413525 (+)  GRCh38
  • Human Ortholog
    FRMD8P1, FERM domain containing 8 pseudogene 1
  • Links
    NCBI Gene ID: 83957
    UniProt: Q9BZ68

  • Chr Location
    Xq12; chrX:65550622-65552421 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable and fertile. Mice homozygous for a conditional allele activated in the intestine exhibit increased AOM/DSS-induced colitis and adenoma formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    720
  • Tissues
    20
  • cDNA Data
    15
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67457 NCBI Gene Model | MGI Sequence Detail 24296 C57BL/6J ±  kb
    transcript NM_026169 RefSeq | MGI Sequence Detail 3166 C57BL/6  
    polypeptide Q3UFK8 UniProt | EBI | MGI Sequence Detail 466 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 15

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1916845, MGI:1918246, MGI:2147645
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 12
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:338904 Yu M, et al., FRMD8 targets both CDK4 activation and RB degradation to suppress colon cancer growth. Cell Rep. 2023 Jul 31;42(8):112886
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory