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Daam1 Gene Detail
Summary
  • Symbol
    Daam1
  • Name
    dishevelled associated activator of morphogenesis 1
  • Synonyms
    1700066F09Rik, 2310028E21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914596
    NCBI Gene: 208846
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:71877852-72039107 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 30.06 cM, cytoband C3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4558 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914596
 protein coding gene Chr12:71877834-72039150 (+)
129S1/SvImJ ENSMUSG00200027694
 protein coding gene Chr12:63790222-63947128 (+)
A/J ENSMUSG00195013118
 protein coding gene Chr12:66495589-66652140 (+)
AKR/J ENSMUSG00220014392
 protein coding gene Chr12:64296715-64457999 (+)
BALB/cJ ENSMUSG00180032180
 protein coding gene Chr12:65494622-65651165 (+)
C3H/HeJ ENSMUSG00175025235
 protein coding gene Chr12:68621514-68778039 (+)
C57BL/6NJ ENSMUSG00215017695
 protein coding gene Chr12:64868005-65029285 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017829
 protein coding gene Chr12:66452400-66609863 (+)
CAST/EiJ ENSTCUG00005033690
 protein coding gene Chr12:64795118-64951572 (+)
CBA/J ENSMUSG00210026919
 protein coding gene Chr12:65058846-65215368 (+)
DBA/2J ENSMUSG00185004732
 protein coding gene Chr12:66957187-67118458 (+)
FVB/NJ ENSMUSG00205029524
 protein coding gene Chr12:64674942-64831059 (+)
JF1/MsJ ENSUMUG00000009705
 protein coding gene Chr12:70906261-71061874 (+)
LP/J ENSMUSG00230021714
 protein coding gene Chr12:73926255-74083159 (+)
NOD/ShiLtJ ENSMUSG00190011541
 protein coding gene Chr12:64125165-64281511 (+)
NZO/HlLtJ ENSMUSG00225037063
 protein coding gene Chr12:75977699-76134610 (+)
PWK/PhJ ENSLUMG00010031162
 protein coding gene Chr12:64971423-65126936 (+)
SPRET/EiJ ENSMSPG00010025033
 protein coding gene Chr12:66663097-66819727 (+)
WSB/EiJ ENSIUOG00005011211
 protein coding gene Chr12:64744856-64906057 (+)



Homology
more
  • Human Ortholog
    DAAM1, dishevelled associated activator of morphogenesis 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DAAM1, dishevelled associated activator of morphogenesis 1
  • Links
    NCBI Gene ID: 23002
    UniProt: Q9Y4D1

  • Chr Location
    14q23.1; chr14:59188646-59371405 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Daam1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 3 alleles in 4 genetic backgrounds
    22 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a gene trap allele show reduced fetal size, partial embryonic and neonatal lethality, altered cytoskeletal structure, cardiac defects including ventricular noncompaction, double outlet right ventricles and ventricular septal defects, and impaired cell adhesion and wound healing.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    894
  • Tissues
    245
  • cDNA Data
    20
  • Literature Summary
    23
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034574 Ensembl Gene Model | MGI Sequence Detail 161256 C57BL/6J ±  kb
    transcript ENSMUST00000223272 Ensembl | MGI Sequence Detail 5835 Not Applicable  
    polypeptide ENSMUSP00000152564 Ensembl | MGI Sequence Detail 1077 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      cDNA 20
      Primer pair 10
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1916850, MGI:2144851
    References
    more
    • Summaries
      All 84
      Developmental Gene Expression 23
      Diseases 1
      Gene Ontology 9
      Phenotypes 23
    • Earliest
      J:10971 Gavin BJ, et al., Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development. Genes Dev. 1990 Dec;4(12B):2319-32
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory