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Wdr45b Gene Detail
Summary
  • Symbol
    Wdr45b
  • Name
    WD repeat domain 45B
  • Synonyms
    0610008N23Rik, D16Bwg0193e, Wdr45l
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914090
    NCBI Gene: 66840
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:121218050-121245271 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 85.24 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    682 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914090
 protein coding gene Chr11:121218029-121246393 (-)
129S1/SvImJ ENSMUSG00200049566
 protein coding gene Chr11:118588810-118615836 (-)
A/J ENSMUSG00195027793
 protein coding gene Chr11:118257791-118285015 (-)
AKR/J ENSMUSG00220027348
 protein coding gene Chr11:118408151-118435371 (-)
BALB/cJ ENSMUSG00180050385
 protein coding gene Chr11:118554208-118581437 (-)
C3H/HeJ ENSMUSG00175045445
 protein coding gene Chr11:118508204-118535424 (-)
C57BL/6NJ ENSMUSG00215045602
 protein coding gene Chr11:118078278-118105500 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017562
 protein coding gene Chr11:117220768-117248155 (-)
CAST/EiJ ENSTCUG00005034013
 protein coding gene Chr11:117923070-117950764 (-)
CBA/J ENSMUSG00210050398
 protein coding gene Chr11:118222246-118249466 (-)
DBA/2J ENSMUSG00185021190
 protein coding gene Chr11:118535401-118562621 (-)
FVB/NJ ENSMUSG00205044243
 protein coding gene Chr11:118381021-118408243 (-)
JF1/MsJ ENSUMUG00000045817
 protein coding gene Chr11:118814558-118852774 (-)
LP/J ENSMUSG00230047591
 protein coding gene Chr11:119596515-119623728 (-)
NOD/ShiLtJ ENSMUSG00190041681
 protein coding gene Chr11:118606607-118633827 (-)
NZO/HlLtJ ENSMUSG00225050937
 protein coding gene Chr11:121766478-121793704 (-)
PWK/PhJ ENSLUMG00010018987
 protein coding gene Chr11:118326108-118353186 (-)
SPRET/EiJ ENSMSPG00010033128
 protein coding gene Chr11:118903484-118930342 (-)
WSB/EiJ ENSIUOG00005045199
 protein coding gene Chr11:118346346-118373365 (-)



Homology
more
  • Human Ortholog
    WDR45B, WD repeat domain 45B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WDR45B, WD repeat domain 45B
  • Synonyms
    NEDSBAS, WDR45L, WIPI-3, WIPI3
  • Links
    NCBI Gene ID: 56270
    UniProt: Q5MNZ6

  • Chr Location
    17q25.3; chr17:82614562-82648553 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotypes from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Conditional homozygous knockout in neurons affects the Golgi apparatus and mitochondria, which impairs alternative autophagy and leads to neuronal degeneration in the brain and motor deficits.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025173 Ensembl Gene Model | MGI Sequence Detail 27222 C57BL/6J ±  kb
    transcript ENSMUST00000026173 Ensembl | MGI Sequence Detail 2321 Not Applicable  
    polypeptide ENSMUSP00000026173 Ensembl | MGI Sequence Detail 344 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 14
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-33993, MGI:106301, MGI:2143985
    References
    more
    • Summaries
      All 39
      Gene Ontology 6
      Phenotypes 8
    • Earliest
      J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory