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Bcs1l Gene Detail
Summary
  • Symbol
    Bcs1l
  • Name
    BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone
  • Synonyms
    9130022O19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914071
    NCBI Gene: 66821
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:74627448-74631602 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 38.54 cM, cytoband C3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    114 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914071
 protein coding gene Chr1:74627448-74631602 (+)
129S1/SvImJ ENSMUSG00200032335
 protein coding gene Chr1:72290523-72294677 (+)
A/J ENSMUSG00195008406
 protein coding gene Chr1:71715326-71719483 (+)
AKR/J ENSMUSG00220010318
 protein coding gene Chr1:71861181-71865335 (+)
BALB/cJ ENSMUSG00180017085
 protein coding gene Chr1:71974159-71978314 (+)
C3H/HeJ ENSMUSG00175015393
 protein coding gene Chr1:72115696-72119852 (+)
C57BL/6NJ ENSMUSG00215010802
 protein coding gene Chr1:72019488-72023643 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014268
 protein coding gene Chr1:68146691-68150831 (+)
CAST/EiJ ENSTCUG00005027484
 protein coding gene Chr1:71744475-71748616 (+)
CBA/J ENSMUSG00210033799
 protein coding gene Chr1:71799955-71804108 (+)
DBA/2J ENSMUSG00185029909
 protein coding gene Chr1:72893845-72897994 (+)
FVB/NJ ENSMUSG00205033606
 protein coding gene Chr1:71469093-71473248 (+)
JF1/MsJ ENSUMUG00000004881
 protein coding gene Chr1:71794269-71798428 (+)
LP/J ENSMUSG00230010042
 protein coding gene Chr1:72883691-72887844 (+)
NOD/ShiLtJ ENSMUSG00190034044
 protein coding gene Chr1:72025718-72029873 (+)
NZO/HlLtJ ENSMUSG00225038829
 protein coding gene Chr1:76098802-76102957 (+)
PWK/PhJ ENSLUMG00010013118
 protein coding gene Chr1:71377892-71382033 (+)
SPRET/EiJ ENSMSPG00010017949
 protein coding gene Chr1:73469463-73473584 (+)
WSB/EiJ ENSIUOG00005012300
 protein coding gene Chr1:71647497-71651651 (+)



Homology
more
  • Human Ortholog
    BCS1L, BCS1 ubiquinol-cytochrome c reductase complex chaperone
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BCS1L, BCS1 ubiquinol-cytochrome c reductase complex chaperone
  • Synonyms
    BCS, BCS1, BJS, FLNMS, GRACILE, h-BCS, h-BCS1, Hs.6719, MC3DN1, PTD
  • Links
    NCBI Gene ID: 617
    UniProt: Q9Y276

  • Chr Location
    2q35; chr2:218658743-218663466 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Bcs1l mouse models; 3 with human BCS1L associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    47 phenotypes from 2 alleles in 3 genetic backgrounds
    1 images
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show decreased embryo size, a rudimentary egg cylinder, failure of primitive streak formation, absent primitive node and headfolds, failure to gastrulate, and complete embryonic lethality by E9.5. Homozygotes for a knock-in allele die prematurely with growth failure, liver glycogen depletion, steatosis, fibrosis and cirrhosis, renal tubulopathy and impaired mitochondrial respiration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    806
  • Tissues
    128
  • cDNA Data
    37
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 66821 NCBI Gene Model | MGI Sequence Detail 4155 C57BL/6J ±  kb
    transcript NM_025784 RefSeq | MGI Sequence Detail 1918 C57BL/6  
    polypeptide Q9CZP5 UniProt | EBI | MGI Sequence Detail 418 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 38
      cDNA 37
      Primer pair 1
      Antibodies 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 3
      Diseases 2
      Gene Ontology 10
      Phenotypes 27
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory