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Cntnap2 Gene Detail
Summary
  • Symbol
    Cntnap2
  • Name
    contactin associated protein-like 2
  • Synonyms
    5430425M22Rik, Caspr2, mKIAA0868
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914047
    NCBI Gene: 66797
  • Alliance
    genome feature page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:45036995-47278330 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 21.81 cM, cytoband B2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    62284 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914047
 protein coding gene Chr6:45036291-47281147 (+)
129S1/SvImJ ENSMUSG00200004708
 protein coding gene Chr6:42117188-44291307 (+)
A/J ENSMUSG00195006394
 protein coding gene Chr6:41997784-44093857 (+)
AKR/J ENSMUSG00220003535
 protein coding gene Chr6:41670251-43798527 (+)
BALB/cJ ENSMUSG00180019794
 protein coding gene Chr6:42192442-44388952 (+)
C3H/HeJ ENSMUSG00175015981
 protein coding gene Chr6:42025631-44158509 (+)
C57BL/6NJ ENSMUSG00215006303
 protein coding gene Chr6:42166731-44334038 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028323
 protein coding gene Chr6:40680727-41760945 (+)
CAST/EiJ ENSTCUG00005004301
 protein coding gene Chr6:41517576-43693377 (+)
CBA/J ENSMUSG00210017687
 protein coding gene Chr6:42082410-44215427 (+)
DBA/2J ENSMUSG00185013501
 protein coding gene Chr6:42178023-44397915 (+)
FVB/NJ ENSMUSG00205022217
 protein coding gene Chr6:44407216-44440711 (+)
FVB/NJ ENSMUSGG00205054327
 protein coding gene Chr6:44225100-44271429 (+)
JF1/MsJ no annotation
LP/J ENSMUSG00230017187
 protein coding gene Chr6:43104722-45354919 (+)
NOD/ShiLtJ ENSMUSG00190028048
 protein coding gene Chr6:41989459-44124054 (+)
NZO/HlLtJ ENSMUSG00225018433
 protein coding gene Chr6:45082128-47332377 (+)
PWK/PhJ ENSLUMG00010020749
 protein coding gene Chr6:41563111-43756812 (+)
SPRET/EiJ ENSMSPG00010008647
 protein coding gene Chr6:42158790-44439417 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    CNTNAP2, contactin associated protein 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CNTNAP2, contactin associated protein 2
  • Synonyms
    AUTS15, CASPR2, CDFE, NRXN4, PTHSL1
  • Links
    NCBI Gene ID: 26047
    UniProt: Q9UHC6

  • Chr Location
    7q35-q36.1; chr7:146116002-148420998 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Cntnap2 mouse models; 10 with human CNTNAP2 associations

Human Disease Mouse Models
      
IDs
 View 2 models
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 3 alleles in 4 genetic backgrounds
    116 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Inactivation of this gene results in molecular abnormalities within the central nervous system, but homozygous mutant mice show no overt phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    195
  • GO References
    51
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    936
  • Tissues
    153
  • cDNA Data
    7
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 66797 NCBI Gene Model | MGI Sequence Detail 2241336 C57BL/6J ±  kb
    transcript NM_001004357 RefSeq | MGI Sequence Detail 7002 C57BL/6  
    polypeptide Q9CPW0 UniProt | EBI | MGI Sequence Detail 1332 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000005673 contactin-associated protein-like 2
      (term hierarchy)
    • InterPro Domains
      IPR000421 Coagulation factor 5/8, C-terminal domain
      IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
      IPR000742 EGF-like domain
      IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
      IPR036056 Fibrinogen-like, C-terminal
      IPR008979 Galactose-binding-like domain superfamily
      IPR042192 Glycophorin-C
      IPR001791 Laminin G domain
      IPR050372 Neurexin-related cell adhesion and synaptic protein
      IPR003585 Neurexin/syndecan/glycophorin C
      IPR060107 Small cell adhesion glycoprotein, transmembrane helix
    • GlyGen
      Q9CPW0 12 sites, 22 N-linked glycans (9 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 7
      Primer pair 3
      Antibodies 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 181
      Developmental Gene Expression 18
      Diseases 2
      Gene Ontology 51
      Phenotypes 116
    • Earliest
      J:309052 Poliak S, et al., Caspr2, a new member of the neurexin superfamily, is localized at the juxtaparanodes of myelinated axons and associates with K+ channels. Neuron. 1999 Dec;24(4):1037-47
    • Latest
      J:391825 Matoba K, et al., Circulating extracellular vesicle microRNAs mediate immune modulation of social behavior in male mice. Nat Commun. 2026 Apr 3;17(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory