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Plag1 Gene Detail
Summary
  • Symbol
    Plag1
  • Name
    pleiomorphic adenoma gene 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891916
    NCBI Gene: 56711
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:3900996-3938423 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 2.18 cM, cytoband A1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    174 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891916
 protein coding gene Chr4:3895209-3938429 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028026
 protein coding gene Chr4:390733-428269 (-)
A/J MGP_AJ_G0027984
 protein coding gene Chr4:458765-501029 (-)
AKR/J MGP_AKRJ_G0027950
 protein coding gene Chr4:401587-440395 (-)
BALB/cJ MGP_BALBcJ_G0027996
 protein coding gene Chr4:432140-469570 (-)
C3H/HeJ MGP_C3HHeJ_G0027726
 protein coding gene Chr4:562594-600257 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028439
 protein coding gene Chr4:552049-592332 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025783
 protein coding gene Chr4:403932-443096 (-)
CAST/EiJ MGP_CASTEiJ_G0027179
 protein coding gene Chr4:473061-514785 (-)
CBA/J MGP_CBAJ_G0027701
 protein coding gene Chr4:426453-469856 (-)
DBA/2J MGP_DBA2J_G0027841
 protein coding gene Chr4:429804-467206 (-)
FVB/NJ MGP_FVBNJ_G0027808
 protein coding gene Chr4:359383-396633 (-)
LP/J MGP_LPJ_G0027952
 protein coding gene Chr4:437507-476477 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027841
 protein coding gene Chr4:609830-650716 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028498
 protein coding gene Chr4:398419-436532 (-)
PWK/PhJ MGP_PWKPhJ_G0026901
 protein coding gene Chr4:491391-532553 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026731
 protein coding gene Chr4:424208-462268 (-)
WSB/EiJ MGP_WSBEiJ_G0027259
 protein coding gene Chr4:544295-582431 (-)



Homology
more
  • Human Ortholog
    PLAG1, PLAG1 zinc finger
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLAG1, PLAG1 zinc finger
  • Synonyms
    PSA, SGPA, SRS4, ZNF912
  • Links
    NCBI Gene ID: 5324
    neXtProt AC: NX_Q6DJT9
    UniProt: Q6DJT9

  • Chr Location
    8q12.1; chr8:56160909-56211324 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human PLAG1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display reduced male fertility, small seminal vesicles and ventral prostate, reduced litter size (females only), reduced embryonic and postnatal growth, and delayed eyelid opening.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1024
  • Tissues
    222
  • cDNA Data
    12
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000003282 Ensembl Gene Model | MGI Sequence Detail 37428 C57BL/6J ±  kb
    transcript ENSMUST00000003369 Ensembl | MGI Sequence Detail 4774 Not Applicable  
    polypeptide ENSMUSP00000003369 Ensembl | MGI Sequence Detail 499 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 12
      Primer pair 4
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 10
      Gene Ontology 6
      Phenotypes 17
    • Earliest
      J:64937 Kas K, et al., Promoter swapping between the genes for a novel zinc finger protein and beta-catenin in pleiomorphic adenomas with t(3;8)(p21;q12) translocations [published erratum appears in Nat Genet 1997 Apr;15(4):411]. Nat Genet. 1997 Feb;15(2):170-4
    • Latest
      J:305360 Tran SC, et al., Effect of Pleomorphic Adenoma Gene 1 Deficiency on Selected Behaviours in Adult Mice. Neuroscience. 2021 Feb 10;455:30-38
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory