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Plag1 Gene Detail
Summary
  • Symbol
    Plag1
  • Name
    pleiomorphic adenoma gene 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891916
    NCBI Gene: 56711
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:3900996-3938423 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 2.18 cM, cytoband A1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    668 from dbSNP Build 142
  • Strain Annotations
    31
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891916
 protein coding gene Chr4:3895209-3938429 (-)
129S1/SvImJ ENSMUSG00200000851
 protein coding gene Chr4:531577-546306 (-)
129S1/SvImJ ENSMUSG00200000857
 protein coding gene Chr4:539487-569010 (-)
A/J ENSMUSG00195002595
 protein coding gene Chr4:944245-958999 (-)
A/J ENSMUSG00195002599
 protein coding gene Chr4:952181-981758 (-)
AKR/J ENSMUSG00220001229
 protein coding gene Chr4:774002-803504 (-)
AKR/J ENSMUSG00220001227
 protein coding gene Chr4:766092-780821 (-)
BALB/cJ ENSMUSG00180004084
 protein coding gene Chr4:533153-562680 (-)
BALB/cJ ENSMUSG00180004077
 protein coding gene Chr4:525243-539972 (-)
C3H/HeJ ENSMUSG00175016109
 protein coding gene Chr4:1057292-1086812 (-)
C3H/HeJ ENSMUSG00175016088
 protein coding gene Chr4:1049382-1064111 (-)
C57BL/6NJ ENSMUSG00215004402
 protein coding gene Chr4:633404-662923 (-)
C57BL/6NJ ENSMUSG00215004399
 protein coding gene Chr4:625494-640223 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025783
 protein coding gene Chr4:403932-443096 (-)
CAST/EiJ ENSTCUG00005024328
 protein coding gene Chr4:811925-827268 (-)
CBA/J ENSMUSG00210002103
 protein coding gene Chr4:789968-804697 (-)
CBA/J ENSMUSG00210002110
 protein coding gene Chr4:797878-827399 (-)
DBA/2J ENSMUSG00185002322
 protein coding gene Chr4:919206-948727 (-)
DBA/2J ENSMUSG00185002316
 protein coding gene Chr4:911296-926025 (-)
FVB/NJ ENSMUSG00205003208
 protein coding gene Chr4:546852-576371 (-)
FVB/NJ ENSMUSG00205003204
 protein coding gene Chr4:538942-553671 (-)
JF1/MsJ ENSUMUG00000001733
 protein coding gene Chr4:1063300-1078635 (-)
LP/J ENSMUSG00230007705
 protein coding gene Chr4:4081999-4096728 (-)
LP/J ENSMUSG00230007740
 protein coding gene Chr4:4089909-4119430 (-)
NOD/ShiLtJ ENSMUSG00190012695
 protein coding gene Chr4:609861-624590 (-)
NOD/ShiLtJ ENSMUSG00190012708
 protein coding gene Chr4:617771-647288 (-)
NZO/HlLtJ ENSMUSG00225000642
 protein coding gene Chr4:8060833-8075562 (-)
NZO/HlLtJ ENSMUSG00225000647
 protein coding gene Chr4:8068743-8098266 (-)
PWK/PhJ ENSLUMG00010005476
 protein coding gene Chr4:515829-531573 (-)
SPRET/EiJ ENSMSPG00010002927
 protein coding gene Chr4:716325-724516 (-)
WSB/EiJ ENSIUOG00005013315
 protein coding gene Chr4:545420-560151 (-)



Homology
more
  • Human Ortholog
    PLAG1, PLAG1 zinc finger
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLAG1, PLAG1 zinc finger
  • Synonyms
    PSA, SGPA, SRS4, ZNF912
  • Links
    NCBI Gene ID: 5324
    UniProt: Q6DJT9

  • Chr Location
    8q12.1; chr8:56160909-56211333 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human PLAG1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 2 alleles in 2 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display reduced male fertility, small seminal vesicles and ventral prostate, reduced litter size (females only), reduced embryonic and postnatal growth, and delayed eyelid opening.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    915
  • Tissues
    222
  • cDNA Data
    12
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000003282 Ensembl Gene Model | MGI Sequence Detail 37428 C57BL/6J ±  kb
    transcript ENSMUST00000003369 Ensembl | MGI Sequence Detail 4774 Not Applicable  
    polypeptide ENSMUSP00000003369 Ensembl | MGI Sequence Detail 499 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 12
      Primer pair 4
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 10
      Gene Ontology 7
      Phenotypes 19
    • Earliest
      J:64937 Kas K, et al., Promoter swapping between the genes for a novel zinc finger protein and beta-catenin in pleiomorphic adenomas with t(3;8)(p21;q12) translocations [published erratum appears in Nat Genet 1997 Apr;15(4):411]. Nat Genet. 1997 Feb;15(2):170-4
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory