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Tollip Gene Detail
Summary
  • Symbol
    Tollip
  • Name
    toll interacting protein
  • Synonyms
    4930403G24Rik, 4931428G15Rik, Toll interacting protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891808
    NCBI Gene: 54473
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:141435317-141456198 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 87.34 cM, cytoband F5
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    425 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891808
 protein coding gene Chr7:141428550-141472244 (-)
129S1/SvImJ ENSMUSG00200040976
 protein coding gene Chr7:127994362-128038076 (-)
A/J ENSMUSG00195037618
 protein coding gene Chr7:132476361-132520065 (-)
AKR/J ENSMUSG00220025320
 protein coding gene Chr7:125958563-126002279 (-)
BALB/cJ ENSMUSG00180032177
 protein coding gene Chr7:129168958-129212668 (-)
C3H/HeJ ENSMUSG00175041318
 protein coding gene Chr7:129897318-129941017 (-)
C57BL/6NJ ENSMUSG00215046561
 protein coding gene Chr7:129163688-129207384 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030710
 protein coding gene Chr7:144046436-144074617 (-)
CAST/EiJ ENSTCUG00005045882
 protein coding gene Chr7:132466021-132509665 (-)
CBA/J ENSMUSG00210025807
 protein coding gene Chr7:129655277-129698990 (-)
DBA/2J ENSMUSG00185015171
 protein coding gene Chr7:133933852-133977547 (-)
FVB/NJ ENSMUSG00205031496
 protein coding gene Chr7:129575997-129619704 (-)
JF1/MsJ ENSUMUG00000031195
 protein coding gene Chr7:139016856-139060571 (-)
LP/J ENSMUSG00230035984
 protein coding gene Chr7:140097222-140140932 (-)
NOD/ShiLtJ ENSMUSG00190022408
 protein coding gene Chr7:129762754-129806455 (-)
NZO/HlLtJ ENSMUSG00225049393
 protein coding gene Chr7:138306142-138349850 (-)
PWK/PhJ ENSLUMG00010038506
 protein coding gene Chr7:128144826-128188449 (-)
SPRET/EiJ ENSMSPG00010032076
 protein coding gene Chr7:129592104-129619520 (-)
WSB/EiJ ENSIUOG00005031761
 protein coding gene Chr7:130495699-130540076 (-)



Homology
more
  • Human Ortholog
    TOLLIP, toll interacting protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TOLLIP, toll interacting protein
  • Synonyms
    IL-1RAcPIP
  • Links
    NCBI Gene ID: 54472
    UniProt: Q9H0E2

  • Chr Location
    11p15.5; chr11:1274371-1310258 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display normal immune cell composition but reduced cytokine production when stimulated with low concentrations of some inducers.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    53
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    621
  • Tissues
    15
  • cDNA Data
    98
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 54473 NCBI Gene Model | MGI Sequence Detail 20882 C57BL/6J ±  kb
    transcript NM_001347562 RefSeq | MGI Sequence Detail 3854 C57BL/6  
    polypeptide Q9QZ06 UniProt | EBI | MGI Sequence Detail 274 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 98
      cDNA 98

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1921868, MGI:1922969
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 1
      Gene Ontology 9
      Phenotypes 26
    • Earliest
      J:64825 Volpe F, et al., The IL1 receptor accessory protein is responsible for the recruitment of the interleukin-1 receptor associated kinase to the IL1/IL1 receptor I complex. FEBS Lett. 1997 Dec 8;419(1):41-4
    • Latest
      J:365053 Hou J, et al., IDR-driven TOLLIP condensates antagonize the innate antiviral immunity by promoting the deSUMOylation of MAVS. Cell Rep. 2025 Mar 25;44(3):115348
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory