About   Help   FAQ
Sall1 Gene Detail
Summary
  • Symbol
    Sall1
  • Name
    spalt like transcription factor 1
  • Synonyms
    Msal-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1889585
    NCBI Gene: 58198
  • Alliance
    genome feature page
  • Transcription Start Sites
    11 TSS
  • Regulated by
    Rr65 (1 regulatory region)
Location &
Maps
more
  • Sequence Map
    Chr8:89753867-89770790 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 43.51 cM, cytoband D
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    273 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1889585
 protein coding gene Chr8:89753863-89770790 (-)
129S1/SvImJ ENSMUSG00200017296
 protein coding gene Chr8:84109569-84126550 (-)
A/J ENSMUSG00195027757
 protein coding gene Chr8:84481037-84497964 (-)
AKR/J ENSMUSG00220038830
 protein coding gene Chr8:84508651-84525634 (-)
BALB/cJ ENSMUSG00180017814
 protein coding gene Chr8:84313211-84330198 (-)
C3H/HeJ ENSMUSG00175022811
 protein coding gene Chr8:84419817-84436746 (-)
C57BL/6NJ ENSMUSG00215025074
 protein coding gene Chr8:84021309-84038234 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031362
 protein coding gene Chr8:80561531-80578452 (-)
CAST/EiJ ENSTCUG00005016492
 protein coding gene Chr8:83881729-83898739 (-)
CBA/J ENSMUSG00210029832
 protein coding gene Chr8:84384451-84401437 (-)
DBA/2J ENSMUSG00185034917
 protein coding gene Chr8:90493081-90510067 (-)
FVB/NJ ENSMUSG00205015149
 protein coding gene Chr8:83440282-83457273 (-)
JF1/MsJ ENSUMUG00000042586
 protein coding gene Chr8:92815458-92832347 (-)
LP/J ENSMUSG00230029617
 protein coding gene Chr8:94106293-94123274 (-)
NOD/ShiLtJ ENSMUSG00190014745
 protein coding gene Chr8:84473744-84490732 (-)
NZO/HlLtJ ENSMUSG00225038892
 protein coding gene Chr8:97510394-97527375 (-)
PWK/PhJ ENSLUMG00010038881
 protein coding gene Chr8:84126151-84143147 (-)
SPRET/EiJ ENSMSPG00010026973
 protein coding gene Chr8:86063394-86080380 (-)
WSB/EiJ ENSIUOG00005017260
 protein coding gene Chr8:85204119-85221131 (-)



Homology
more
  • Human Ortholog
    SALL1, spalt like transcription factor 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SALL1, spalt like transcription factor 1
  • Synonyms
    HEL-S-89, HSAL1, Sal-1, TBS, ZNF794
  • Links
    NCBI Gene ID: 6299
    UniProt: Q9NSC2

  • Chr Location
    16q12.1; chr16:51135982-51152683 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Sall1 mouse models; 3 with human SALL1 associations

Human Disease Mouse Models
      
IDs
 View 3 models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    45 phenotypes from 11 alleles in 10 genetic backgrounds
    19 phenotypes from multigenic genotypes
    103 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit kidney agenesis or dysgenesis and die perinatally. Homozygotes expressing only a truncated protein show renal agenesis, exencephaly, and limb defects; heterozygotes have hearing loss and cystic kidneys.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    82
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1369
  • Tissues
    382
  • cDNA Data
    52
  • Literature Summary
    102
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 58198 NCBI Gene Model | MGI Sequence Detail 16924 C57BL/6J ±  kb
    transcript NM_001371070 RefSeq | MGI Sequence Detail 5543 C57BL/6  
    polypeptide Q9ER74 UniProt | EBI | MGI Sequence Detail 1322 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 71
      Genomic 3
      cDNA 54
      Primer pair 8
      Other 6
      Antibodies 5

      Microarray probesets 4
    References
    more
    • Summaries
      All 216
      Developmental Gene Expression 102
      Diseases 2
      Gene Ontology 20
      Phenotypes 103
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
    • Latest
      J:391671 Ratzabi A, et al., Brain metastases exhibit distinct spatial patterns of resident and infiltrating macrophages. Cell Death Discov. 2026 Apr 1;12(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory