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Cadm1 Gene Detail
Summary
  • Symbol
    Cadm1
  • Name
    cell adhesion molecule 1
  • Synonyms
    2900073G06Rik, 3100001I08Rik, Igsf4, Igsf4a, Necl2, RA175A, RA175B, RA175C, RA175N, SgIGSF, SynCam, Tslc1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1889272
    NCBI Gene: 54725
  • Alliance
  • Transcription Start Sites
    39 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:47441471-47769413 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 9, 25.83 cM, cytoband B-C
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6594 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1889272
protein coding gene Chr9:47441468-47773578 (+)
129S1/SvImJ ENSMUSG00200018052
protein coding gene Chr9:44568558-44895138 (+)
A/J ENSMUSG00195018170
protein coding gene Chr9:44292004-44618581 (+)
AKR/J ENSMUSG00220030647
protein coding gene Chr9:44379945-44706642 (+)
BALB/cJ ENSMUSG00180026742
protein coding gene Chr9:44403477-44730056 (+)
C3H/HeJ ENSMUSG00175012295
protein coding gene Chr9:44415718-44742268 (+)
C57BL/6NJ ENSMUSG00215027595
protein coding gene Chr9:44362259-44690287 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032162
protein coding gene Chr9:44391372-44718105 (+)
CAST/EiJ ENSTCUG00005014573
protein coding gene Chr9:44351149-44678036 (+)
CBA/J ENSMUSG00210016086
protein coding gene Chr9:44455724-44783852 (+)
DBA/2J ENSMUSG00185011736
protein coding gene Chr9:44530008-44856544 (+)
FVB/NJ ENSMUSG00205023495
protein coding gene Chr9:44769755-45096382 (+)
JF1/MsJ ENSUMUG00000011905
protein coding gene Chr9:44584227-44912310 (+)
LP/J ENSMUSG00230038584
protein coding gene Chr9:44823301-45149874 (+)
NOD/ShiLtJ ENSMUSG00190023679
protein coding gene Chr9:44608525-44935061 (+)
NZO/HlLtJ ENSMUSG00225041602
protein coding gene Chr9:44784089-45112098 (+)
PWK/PhJ ENSLUMG00010019613
protein coding gene Chr9:44532145-44878732 (+)
SPRET/EiJ ENSMSPG00010010190
protein coding gene Chr9:45311257-45637787 (+)
WSB/EiJ ENSIUOG00005018219
protein coding gene Chr9:44027365-44353931 (+)



Homology
more
  • Human Ortholog
    CADM1, cell adhesion molecule 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CADM1, cell adhesion molecule 1
  • Synonyms
    BL2, IGSF4, IGSF4A, Necl-2, NECL2, RA175, sgIGSF, ST17, sTSLC-1, SYNCAM, synCAM1, TSLC1
  • Links
    NCBI Gene ID: 23705
    UniProt: Q9BY67

  • Chr Location
    11q23.3; chr11:115169218-115504957 (-)  GRCh38

Human Diseases
more
  • Diseases
    2 with human CADM1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    38 phenotypes from 7 alleles in 8 genetic backgrounds
    54 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant male mice show infertility due to block in maturation of spermatogenesis. Mice homozygous for a gene trap allele exhibit decreased body size, impaired T cell development, and impaired T cell response to anti-CD3/CD28 antibody stimulation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032076 Ensembl Gene Model | MGI Sequence Detail 327943 C57BL/6J ±  kb
    transcript ENSMUST00000152459 Ensembl | MGI Sequence Detail 1784 Not Applicable  
    polypeptide ENSMUSP00000124119 Ensembl | MGI Sequence Detail 474 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 148
      cDNA 145
      Primer pair 2
      Other 1
      Antibodies 6

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1919652, MGI:1920304, MGI:2143168
    References
    more
    • Summaries
      All 163
      Developmental Gene Expression 33
      Gene Ontology 22
      Phenotypes 54
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:371487 Tseng CS, et al., A developmental gradient of COUP-TFI expression regulates the relative size of hippocampus dorsal and ventral subregions. PLoS Biol. 2025 Aug;23(8):e3003355

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    09/01/2026
    MGI 6.24
    The Jackson Laboratory