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Actl6a Gene Detail
Summary
  • Symbol
    Actl6a
  • Name
    actin-like 6A
  • Synonyms
    2810432C06Rik, Actl6, ARP4, Baf53a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1861453
    NCBI Gene: 56456
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:32762695-32781122 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 15.83 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    158 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1861453
 protein coding gene Chr3:32760447-32781122 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027141
 protein coding gene Chr3:30329003-30350756 (+)
A/J MGP_AJ_G0027101
 protein coding gene Chr3:29895577-29920493 (+)
AKR/J MGP_AKRJ_G0027070
 protein coding gene Chr3:30367249-30387505 (+)
BALB/cJ MGP_BALBcJ_G0027113
 protein coding gene Chr3:29548095-29568770 (+)
C3H/HeJ MGP_C3HHeJ_G0026856
 protein coding gene Chr3:30384859-30405534 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027559
 protein coding gene Chr3:31835574-31856352 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024920
 protein coding gene Chr3:27714345-27734916 (+)
CAST/EiJ MGP_CASTEiJ_G0026309
 protein coding gene Chr3:30250250-30271403 (+)
CBA/J MGP_CBAJ_G0026833
 protein coding gene Chr3:32696686-32717361 (+)
DBA/2J MGP_DBA2J_G0026967
 protein coding gene Chr3:29360054-29380342 (+)
FVB/NJ MGP_FVBNJ_G0026935
 protein coding gene Chr3:28819946-28840240 (+)
LP/J MGP_LPJ_G0027079
 protein coding gene Chr3:31096872-31117126 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026955
 protein coding gene Chr3:35188259-35209824 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027618
 protein coding gene Chr3:30148537-30168782 (+)
PWK/PhJ MGP_PWKPhJ_G0026042
 protein coding gene Chr3:28901380-28922929 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025854
 protein coding gene Chr3:29579433-29598779 (+)
WSB/EiJ MGP_WSBEiJ_G0026383
 protein coding gene Chr3:30181160-30201938 (+)



Homology
more
  • Human Ortholog
    ACTL6A, actin like 6A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ACTL6A, actin like 6A
  • Synonyms
    ACTL6, Arp4, ARPN-BETA, BAF53A, INO80K, SMARCN1
  • Links
    NCBI Gene ID: 86
    neXtProt AC: NX_O96019
    UniProt: O96019

  • Chr Location
    3q26.33; chr3:179562886-179588407 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 3 alleles in 3 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic lethality before E6.5. Mice homozygous for a conditional allele activated in hematopoietic cells exhibit bone marrow failure and premature death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    78
  • GO References
    36
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    944
  • Tissues
    67
  • cDNA Data
    16
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56456 NCBI Gene Model | MGI Sequence Detail 18428 C57BL/6J ±  kb
    transcript NM_019673 RefSeq | MGI Sequence Detail 1818 C57BL/6  
    polypeptide Q9Z2N8 UniProt | EBI | MGI Sequence Detail 429 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 16
      Primer pair 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1919992, MGI:2139823, MGI:2140068
    References
    more
    • Summaries
      All 86
      Developmental Gene Expression 16
      Diseases 1
      Gene Ontology 36
      Phenotypes 14
    • Earliest
      J:320308 Valka I, et al., Separation and Quantification of Some Alkaloids from Fumaria parviflora by Capillary Isotachophoresis1. Planta Med. 1985 Aug;51(4):319-22
    • Latest
      J:330574 Fulton SL, et al., Rescue of deficits by Brwd1 copy number restoration in the Ts65Dn mouse model of Down syndrome. Nat Commun. 2022 Oct 26;13(1):6384
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory