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Snx3 Gene Detail
Summary
  • Symbol
    Snx3
  • Name
    sorting nexin 3
  • Synonyms
    SDP3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860188
    NCBI Gene: 54198
  • Alliance
    genome feature page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:42378050-42411365 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 22.89 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    846 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1860188
 protein coding gene Chr10:42378026-42411377 (+)
129S1/SvImJ ENSMUSG00200008678
 protein coding gene Chr10:39255434-39288837 (+)
A/J ENSMUSG00195016817
 protein coding gene Chr10:39539870-39573226 (+)
AKR/J ENSMUSG00220026185
 protein coding gene Chr10:39229087-39262444 (+)
BALB/cJ ENSMUSG00180015956
 protein coding gene Chr10:39624021-39657378 (+)
C3H/HeJ ENSMUSG00175010979
 protein coding gene Chr10:39419117-39452469 (+)
C57BL/6NJ ENSMUSG00215007324
 protein coding gene Chr10:39168467-39201821 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015279
 protein coding gene Chr10:37914391-37947042 (+)
CAST/EiJ ENSTCUG00005027146
 protein coding gene Chr10:39617784-39650864 (+)
CBA/J ENSMUSG00210025060
 protein coding gene Chr10:39312648-39346000 (+)
DBA/2J ENSMUSG00185006598
 protein coding gene Chr10:39465225-39498577 (+)
FVB/NJ ENSMUSG00205010953
 protein coding gene Chr10:39380502-39413856 (+)
JF1/MsJ ENSUMUG00000032737
 protein coding gene Chr10:39246231-39278841 (+)
LP/J ENSMUSG00230005506
 protein coding gene Chr10:41245212-41278614 (+)
NOD/ShiLtJ ENSMUSG00190031063
 protein coding gene Chr10:39593320-39626675 (+)
NZO/HlLtJ ENSMUSG00225017595
 protein coding gene Chr10:45558183-45591535 (+)
PWK/PhJ ENSLUMG00010007588
 protein coding gene Chr10:39362032-39394706 (+)
SPRET/EiJ ENSMSPG00010019791
 protein coding gene Chr10:40391750-40425226 (+)
WSB/EiJ ENSIUOG00005014721
 protein coding gene Chr10:39136921-39170314 (+)



Homology
more
  • Human Ortholog
    SNX3, sorting nexin 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SNX3, sorting nexin 3
  • Synonyms
    Grd19, MCOPS8, SDP3
  • Links
    NCBI Gene ID: 8724
    UniProt: O60493

  • Chr Location
    6q21; chr6:108211222-108261255 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 1 allele in 1 genetic background
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    55
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    845
  • Tissues
    109
  • cDNA Data
    225
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 54198 NCBI Gene Model | MGI Sequence Detail 33316 C57BL/6J ±  kb
    transcript NM_017472 RefSeq | MGI Sequence Detail 1377 ZRU/MplStud  
    polypeptide O70492 UniProt | EBI | MGI Sequence Detail 162 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 229
      Genomic 1
      cDNA 226
      Primer pair 1
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 5
      Gene Ontology 9
      Phenotypes 19
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:379502 Li H, et al., SNX3 mediates heart failure by interacting with HMGB1 and subsequently facilitating its nuclear-cytoplasmic translocation. Acta Pharmacol Sin. 2025 Apr;46(4):964-975
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory