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Gtpbp2 Gene Detail
Summary
  • Symbol
    Gtpbp2
  • Name
    GTP binding protein 2
  • Synonyms
    nmf205
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860138
    NCBI Gene: 56055
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:46471958-46480296 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 22.89 cM, cytoband C-D
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    17 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1860138
 protein coding gene Chr17:46470153-46480296 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023804
 protein coding gene Chr17:47207081-47215416 (+)
A/J MGP_AJ_G0023762
 protein coding gene Chr17:46069406-46077744 (+)
AKR/J MGP_AKRJ_G0023733
 protein coding gene Chr17:46403936-46412274 (+)
BALB/cJ MGP_BALBcJ_G0023766
 protein coding gene Chr17:45973720-45982064 (+)
C3H/HeJ MGP_C3HHeJ_G0023530
 protein coding gene Chr17:47130751-47139089 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024209
 protein coding gene Chr17:49251463-49259801 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021659
 protein coding gene Chr17:42870653-42879259 (+)
CAST/EiJ MGP_CASTEiJ_G0023011
 protein coding gene Chr17:47253704-47267306 (+)
CBA/J MGP_CBAJ_G0023506
 protein coding gene Chr17:51005439-51013767 (+)
DBA/2J MGP_DBA2J_G0023632
 protein coding gene Chr17:44859880-44868218 (+)
FVB/NJ MGP_FVBNJ_G0023599
 protein coding gene Chr17:44461763-44470098 (+)
LP/J MGP_LPJ_G0023713
 protein coding gene Chr17:47875283-47883679 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023628
 protein coding gene Chr17:50571371-50583185 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024254
 protein coding gene Chr17:46753935-46762293 (+)
PWK/PhJ MGP_PWKPhJ_G0022756
 protein coding gene Chr17:44175775-44184140 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022571
 protein coding gene Chr17:43654379-43662689 (+)
WSB/EiJ MGP_WSBEiJ_G0023076
 protein coding gene Chr17:47305298-47313638 (+)



Homology
more
  • Human Ortholog
    GTPBP2, GTP binding protein 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GTPBP2, GTP binding protein 2
  • Synonyms
    JABELS
  • Links
    NCBI Gene ID: 54676
    neXtProt AC: NX_Q9BX10
    UniProt: Q9BX10

  • Chr Location
    6p21.1; chr6:43605316-43631333 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    19 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    746
  • Tissues
    31
  • cDNA Data
    109
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000023952 Ensembl Gene Model | MGI Sequence Detail 8339 C57BL/6J ±  kb
    transcript ENSMUST00000172170 Ensembl | MGI Sequence Detail 2587 Not Applicable  
    polypeptide ENSMUSP00000128517 Ensembl | MGI Sequence Detail 604 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000008334 GTP-binding protein 2
      (term hierarchy)
    • InterPro Domains
      IPR035531 GTP binding protein 1-like, GTP-binding domain
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
      IPR000795 Translational (tr)-type GTP-binding domain
      IPR009001 Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal
      IPR009000 Translation protein, beta-barrel domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 109
      cDNA 109

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2681952
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 18
    • Earliest
      J:62657 Kudo H, et al., Mouse and human GTPBP2, newly identified members of the GP-1 family of GTPase. Biochem Biophys Res Commun. 2000 Jun 7;272(2):456-65
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory