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Ero1a Gene Detail
Summary
  • Symbol
    Ero1a
  • Name
    endoplasmic reticulum oxidoreductase 1 alpha
  • Synonyms
    Ero1l
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354385
    NCBI Gene: 50527
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:45520544-45556029 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 22.86 cM, cytoband C-D
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    134 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1354385
 protein coding gene Chr14:45520544-45556228 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021206
 protein coding gene Chr14:38901183-38939913 (-)
A/J MGP_AJ_G0021152
 protein coding gene Chr14:37746417-37783430 (-)
AKR/J MGP_AKRJ_G0021130
 protein coding gene Chr14:39228690-39266998 (-)
BALB/cJ MGP_BALBcJ_G0021156
 protein coding gene Chr14:37798807-37833780 (-)
C3H/HeJ MGP_C3HHeJ_G0020939
 protein coding gene Chr14:39036536-39074524 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021590
 protein coding gene Chr14:40598465-40634175 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019149
 protein coding gene Chr14:37171010-37211556 (-)
CAST/EiJ MGP_CASTEiJ_G0020464
 protein coding gene Chr14:36148693-36191686 (-)
CBA/J MGP_CBAJ_G0020905
 protein coding gene Chr14:41881160-41928418 (-)
DBA/2J MGP_DBA2J_G0021028
 protein coding gene Chr14:37668869-37705934 (-)
FVB/NJ MGP_FVBNJ_G0021012
 protein coding gene Chr14:37428046-37463361 (-)
LP/J MGP_LPJ_G0021098
 protein coding gene Chr14:39186704-39227444 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021038
 protein coding gene Chr14:41290180-41329431 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021623
 protein coding gene Chr14:38767028-38804294 (-)
PWK/PhJ MGP_PWKPhJ_G0020213
 protein coding gene Chr14:34530481-34566669 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020035
 protein coding gene Chr14:34921583-34960609 (-)
WSB/EiJ MGP_WSBEiJ_G0020520
 protein coding gene Chr14:38874235-38915440 (-)



Homology
more
  • Human Ortholog
    ERO1A, endoplasmic reticulum oxidoreductase 1 alpha
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ERO1A, endoplasmic reticulum oxidoreductase 1 alpha
  • Synonyms
    Ero1alpha, ERO1-alpha, ERO1L, ERO1-L, ERO1LA, ERO1-L-alpha
  • Links
    NCBI Gene ID: 30001
    neXtProt AC: NX_Q96HE7
    UniProt: Q96HE7

  • Chr Location
    14q22.1; chr14:52639915-52695900 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit decreased apoptosis and calcium release in macrophages exposed to endoplasmic reticulum stress.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    715
  • Tissues
    9
  • cDNA Data
    196
  • Literature Summary
    6
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 50527 NCBI Gene Model | MGI Sequence Detail 35486 C57BL/6J ±  kb
transcript NM_015774 RefSeq | MGI Sequence Detail 4435 C57BL/6  
polypeptide Q8R180 UniProt | EBI | MGI Sequence Detail 464 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 198
    cDNA 197
    Primer pair 1

    Microarray probesets 6
References
more
  • Summaries
    All 58
    Developmental Gene Expression 6
    Gene Ontology 14
    Phenotypes 17
  • Earliest
    J:60564 Cabibbo A, et al., ERO1-L, a human protein that favors disulfide bond formation in the endoplasmic reticulum. J Biol Chem. 2000 Feb 18;275(7):4827-33
  • Latest
    J:345334 Xie H, et al., SUMOylation of ERp44 enhances Ero1alpha ER retention contributing to the pathogenesis of obesity and insulin resistance. Metabolism. 2023 Feb;139:155351
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory