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Hsf4 Gene Detail
Summary
  • Symbol
    Hsf4
  • Name
    heat shock transcription factor 4
  • Synonyms
    ldis1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347058
    NCBI Gene: 26386
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:105996433-106002477 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 53.04 cM, cytoband D1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    11 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347058
 protein coding gene Chr8:105996392-106002477 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034033
 protein coding gene Chr8:107535118-107541162 (+)
A/J MGP_AJ_G0034014
 protein coding gene Chr8:103247760-103253804 (+)
AKR/J MGP_AKRJ_G0033940
 protein coding gene Chr8:106231765-106237813 (+)
BALB/cJ MGP_BALBcJ_G0034007
 protein coding gene Chr8:103422918-103428962 (+)
C3H/HeJ MGP_C3HHeJ_G0033719
 protein coding gene Chr8:106977633-106983673 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034527
 protein coding gene Chr8:111484304-111490348 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031469
 protein coding gene Chr8:96396730-96403354 (+)
CAST/EiJ MGP_CASTEiJ_G0033045
 protein coding gene Chr8:106476553-106482619 (+)
CBA/J MGP_CBAJ_G0033692
 protein coding gene Chr8:115081688-115087738 (+)
DBA/2J MGP_DBA2J_G0033847
 protein coding gene Chr8:102592339-102598383 (+)
FVB/NJ MGP_FVBNJ_G0033793
 protein coding gene Chr8:101515975-101522024 (+)
LP/J MGP_LPJ_G0033938
 protein coding gene Chr8:107746243-107752287 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033836
 protein coding gene Chr8:118294515-118300559 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034545
 protein coding gene Chr8:106205755-106211799 (+)
PWK/PhJ MGP_PWKPhJ_G0032746
 protein coding gene Chr8:101977415-101983582 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032587
 protein coding gene Chr8:104881426-104888943 (+)
WSB/EiJ MGP_WSBEiJ_G0033161
 protein coding gene Chr8:106858853-106864901 (+)



Homology
more
  • Human Ortholog
    HSF4, heat shock transcription factor 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HSF4, heat shock transcription factor 4
  • Synonyms
    CTM, CTRCT5
  • Links
    NCBI Gene ID: 3299
    neXtProt AC: NX_Q9ULV5
    UniProt: Q9ULV5

  • Chr Location
    16q22.1; chr16:67163761-67169945 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Hsf4 mouse models; 2 with human HSF4 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 6 alleles in 7 genetic backgrounds
    2 phenotypes from multigenic genotypes
    3 images
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display abnormal lens morphology and cataracts.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    765
  • Tissues
    49
  • cDNA Data
    10
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033249 Ensembl Gene Model | MGI Sequence Detail 6045 C57BL/6J ±  kb
    transcript ENSMUST00000036127 Ensembl | MGI Sequence Detail 1739 Not Applicable  
    polypeptide ENSMUSP00000048904 Ensembl | MGI Sequence Detail 492 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000008793 heat shock factor protein 4
      (term hierarchy)
    • InterPro Domains
      IPR000232 Heat shock factor (HSF)-type, DNA-binding
      IPR027725 Heat shock transcription factor family
      IPR036390 Winged helix DNA-binding domain superfamily
      IPR036388 Winged helix-like DNA-binding domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 10
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:3056558
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 11
      Diseases 2
      Gene Ontology 5
      Phenotypes 22
    • Earliest
      J:57773 Tanabe M, et al., The mammalian HSF4 gene generates both an activator and a repressor of heat shock genes by alternative splicing. J Biol Chem. 1999 Sep 24;274(39):27845-56
    • Latest
      J:341021 Zhang J, et al., HSF4 Transcriptionally Activates Autophagy by Regulating ATG9a During Lens Terminal Differentiation. Invest Ophthalmol Vis Sci. 2023 Jun 1;64(7):5
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory