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Map2k3 Gene Detail
Summary
  • Symbol
    Map2k3
  • Name
    mitogen-activated protein kinase kinase 3
  • Synonyms
    MAP kinase kinase 3, MKK3, Prkmk3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346868
    NCBI Gene: 26397
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:60822880-60843637 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 11, 37.95 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    178 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346868
protein coding gene Chr11:60822859-60843637 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018430
protein coding gene Chr11:60860036-60884441 (+)
A/J MGP_AJ_G0018399
protein coding gene Chr11:58618833-58639531 (+)
AKR/J MGP_AKRJ_G0018369
protein coding gene Chr11:60464919-60485691 (+)
BALB/cJ MGP_BALBcJ_G0018370
protein coding gene Chr11:58922760-58943888 (+)
C3H/HeJ MGP_C3HHeJ_G0018183
protein coding gene Chr11:60419969-60443787 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018822
protein coding gene Chr11:62794132-62815657 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016468
protein coding gene Chr11:55757049-55777821 (+)
CAST/EiJ MGP_CASTEiJ_G0017740
protein coding gene Chr11:60527804-60551201 (+)
CBA/J MGP_CBAJ_G0018157
protein coding gene Chr11:65521956-65546230 (+)
DBA/2J MGP_DBA2J_G0018266
protein coding gene Chr11:58204465-58225232 (+)
FVB/NJ MGP_FVBNJ_G0018257
protein coding gene Chr11:57870947-57892395 (+)
LP/J MGP_LPJ_G0018339
protein coding gene Chr11:61437050-61457853 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018281
protein coding gene Chr11:66568276-66588999 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018863
protein coding gene Chr11:60575789-60600282 (+)
PWK/PhJ MGP_PWKPhJ_G0017513
protein coding gene Chr11:58785163-58810366 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017303
protein coding gene Chr11:60385605-60406273 (+)
WSB/EiJ MGP_WSBEiJ_G0017792
protein coding gene Chr11:60187738-60208466 (+)



Homology
more
  • Human Ortholog
    MAP2K3, mitogen-activated protein kinase kinase 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAP2K3, mitogen-activated protein kinase kinase 3
  • Synonyms
    MAPKK3, MEK3, MKK3, PRKMK3, SAPKK2, SAPKK-2
  • Links
    NCBI Gene ID: 5606
    neXtProt AC: NX_P46734
    UniProt: P46734

  • Chr Location
    17p11.2; chr17:21284672-21315240 (+)  GRCh38

Human Diseases
more
  • Diseases
    2 with human MAP2K3 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 2 genetic backgrounds
    9 phenotypes from multigenic genotypes
    73 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    21
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    4
  • Gene trapped
    7
  • Targeted
    8
  • Transgenic
    1
  • Genomic Mutations
    3 involving Map2k3
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
Mice homozygous for disruptions in this gene are viable and fertile but display abnormalities in cytokine production.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 26397 NCBI Gene Model | MGI Sequence Detail 20758 C57BL/6J ±  kb
transcript NM_008928 RefSeq | MGI Sequence Detail 2177 C57BL/6  
polypeptide O09110 UniProt | EBI | MGI Sequence Detail 347 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 163
    cDNA 161
    Primer pair 2

    Microarray probesets 6
Other
Accession IDs
less
MGI:1328353, MGI:2144511
References
more
  • Summaries
    All 120
    Developmental Gene Expression 7
    Diseases 2
    Gene Ontology 12
    Phenotypes 73
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:334031 Crespo M, et al., Myeloid p38 activation maintains macrophage-liver crosstalk and BAT thermogenesis through IL-12-FGF21 axis. Hepatology. 2023 Mar 1;77(3):874-887

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory