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Psmb9 Gene Detail
Summary
  • Symbol
    Psmb9
  • Name
    proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)
  • Synonyms
    Lmp-2, Lmp2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346526
    NCBI Gene: 16912
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:34401006-34406347 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 17.98 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • Strain Annotations
    10
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346526
 protein coding gene Chr17:34400961-34406738 (-)
129S1/SvImJ ENSMUSG00200049936
 protein coding gene Chr17:30104116-30105811 (-)
129S1/SvImJ ENSMUSGG00200054996
 protein coding gene Chr17:30106236-30109445 (-)
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ ENSMUSG00215051121
 protein coding gene Chr17:29944294-29945989 (-)
C57BL/6NJ ENSMUSGG00215055840
 protein coding gene Chr17:29946414-29949623 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021446
 protein coding gene Chr17:30513520-30519177 (-)
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
JF1/MsJ no annotation
LP/J ENSMUSG00230053605
 protein coding gene Chr17:33502464-33504159 (-)
LP/J ENSMUSGG00230055943
 protein coding gene Chr17:33504584-33507793 (-)
NOD/ShiLtJ no annotation
NZO/HlLtJ ENSMUSG00225053922
 protein coding gene Chr17:35545512-35551322 (-)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010037138
 protein coding gene Chr17:30626393-30632172 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    PSMB9, proteasome 20S subunit beta 9
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PSMB9, proteasome 20S subunit beta 9
  • Synonyms
    beta1i, LMP2, PRAAS3, PRAAS6, PSMB6i, RING12
  • Links
    NCBI Gene ID: 5698
    UniProt: P28065

  • Chr Location
    6p21.32; chr6:32844136-32860734 (+)  GRCh38
Human Diseases
more
  • Diseases
    7 with human PSMB9 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    8 phenotypes from multigenic genotypes
    47 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene have a grossly normal phenotype but suffer from increased susceptibility to some viruses and have an increased risk of tumor development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    22
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    602
  • Tissues
    1
  • cDNA Data
    23
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16912 NCBI Gene Model | MGI Sequence Detail 5342 C57BL/6J ±  kb
    transcript NM_001413205 RefSeq | MGI Sequence Detail 1108 ZRU/MplStud  
    polypeptide O35522 UniProt | EBI | MGI Sequence Detail 219 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 52
      Genomic 23
      cDNA 23
      Primer pair 4
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11821, MGD-MRK-11823, MGI:96797
    References
    more
    • Summaries
      All 116
      Developmental Gene Expression 3
      Gene Ontology 12
      Phenotypes 47
    • Earliest
      J:8266 Monaco JJ, et al., The LMP antigens: a stable MHC-controlled multisubunit protein complex. Hum Immunol. 1986 Apr;15(4):416-26
    • Latest
      J:371829 de la Visitacion N, et al., Immunoproteasomal Processing of IsoLG-Adducted Proteins Is Essential for Hypertension. Circ Res. 2024 May 10;134(10):1276-1291
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory