About   Help   FAQ
Mrps12 Gene Detail
Summary
  • Symbol
    Mrps12
  • Name
    mitochondrial ribosomal protein S12
  • Synonyms
    mitoribosomal protein s12, Rpms12, rps12
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346333
    NCBI Gene: 24030
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:28439066-28441245 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 16.91 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    24 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346333
 protein coding gene Chr7:28439066-28441246 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031956
 protein coding gene Chr7:27567852-27573684 (-)
A/J MGP_AJ_G0031934
 protein coding gene Chr7:26886179-26888414 (-)
AKR/J MGP_AKRJ_G0031866
 protein coding gene Chr7:27576307-27580167 (-)
BALB/cJ MGP_BALBcJ_G0031941
 protein coding gene Chr7:27045538-27047792 (-)
C3H/HeJ MGP_C3HHeJ_G0031660
 protein coding gene Chr7:27954519-27956690 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032405
 protein coding gene Chr7:28471426-28474404 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029457
 protein coding gene Chr7:27946947-27949342 (-)
CAST/EiJ MGP_CASTEiJ_G0030995
 protein coding gene Chr7:21273862-21276161 (-)
CBA/J MGP_CBAJ_G0031626
 protein coding gene Chr7:29740217-29746385 (-)
DBA/2J MGP_DBA2J_G0031778
 protein coding gene Chr7:26638777-26641974 (-)
FVB/NJ MGP_FVBNJ_G0031735
 protein coding gene Chr7:26715216-26717461 (-)
LP/J MGP_LPJ_G0031858
 protein coding gene Chr7:27897611-27901467 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031771
 protein coding gene Chr7:29206769-29211732 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032435
 protein coding gene Chr7:27055585-27059630 (-)
PWK/PhJ MGP_PWKPhJ_G0030720
 protein coding gene Chr7:21663256-21665555 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030553
 protein coding gene Chr7:18076250-18078423 (-)
WSB/EiJ MGP_WSBEiJ_G0031104
 protein coding gene Chr7:27424013-27428781 (-)



Homology
more
  • Human Ortholog
    MRPS12, mitochondrial ribosomal protein S12
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MRPS12, mitochondrial ribosomal protein S12
  • Synonyms
    MPR-S12, MT-RPS12, RPMS12, RPS12, RPSM12, uS12m
  • Links
    NCBI Gene ID: 6183
    neXtProt AC: NX_O15235
    UniProt: O15235

  • Chr Location
    19q13.2; chr19:38930944-38933168 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 3 alleles in 3 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an error-prone encoding allele exhibit reduced mitochondrial translation and levels of complex IV, and increased polyploid cells in the liver, hepatocyte proliferation, and mitochondiral DNA content. Mice homozygous for a hyper-active encoding allele exhibit reduced mitochondrial translation and dilated cardiomyopathy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    720
  • Tissues
    13
  • cDNA Data
    76
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000045948 Ensembl Gene Model | MGI Sequence Detail 2180 C57BL/6J ±  kb
    transcript ENSMUST00000056078 Ensembl | MGI Sequence Detail 722 Not Applicable  
    polypeptide ENSMUSP00000062066 Ensembl | MGI Sequence Detail 139 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 77
      cDNA 76
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2141924
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 1
      Gene Ontology 8
      Phenotypes 7
    • Earliest
      J:57556 Shah ZH, et al., Metazoan nuclear genes for mitoribosomal protein S12. Gene. 1997 Dec 19;204(1-2):55-62
    • Latest
      J:343856 Richman TR, et al., Mitochondrial mistranslation modulated by metabolic stress causes cardiovascular disease and reduced lifespan. Aging Cell. 2021 Jul;20(7):e13408
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory