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Hdac3 Gene Detail
Summary
  • Symbol
    Hdac3
  • Name
    histone deacetylase 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1343091
    NCBI Gene: 15183
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:38070024-38088073 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 19.81 cM, cytoband B3
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    167 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1343091
 protein coding gene Chr18:38068897-38088073 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024355
 protein coding gene Chr18:36357597-36377656 (-)
A/J MGP_AJ_G0024322
 protein coding gene Chr18:35105620-35124688 (-)
AKR/J MGP_AKRJ_G0024291
 protein coding gene Chr18:36068543-36087592 (-)
BALB/cJ MGP_BALBcJ_G0024322
 protein coding gene Chr18:35171513-35191045 (-)
C3H/HeJ MGP_C3HHeJ_G0024088
 protein coding gene Chr18:36134899-36153822 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024764
 protein coding gene Chr18:37657116-37677190 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022203
 protein coding gene Chr18:35125624-35144812 (-)
CAST/EiJ MGP_CASTEiJ_G0023563
 protein coding gene Chr18:36075710-36094693 (-)
CBA/J MGP_CBAJ_G0024058
 protein coding gene Chr18:38771307-38790423 (-)
DBA/2J MGP_DBA2J_G0024188
 protein coding gene Chr18:34705421-34725180 (-)
FVB/NJ MGP_FVBNJ_G0024154
 protein coding gene Chr18:34416214-34435538 (-)
LP/J MGP_LPJ_G0024272
 protein coding gene Chr18:36422394-36441501 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024185
 protein coding gene Chr18:40024460-40043379 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024813
 protein coding gene Chr18:35933817-35952716 (-)
PWK/PhJ MGP_PWKPhJ_G0023307
 protein coding gene Chr18:34915300-34934316 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023112
 protein coding gene Chr18:36150293-36169402 (-)
WSB/EiJ MGP_WSBEiJ_G0023626
 protein coding gene Chr18:35833825-35852959 (-)



Homology
more
  • Human Ortholog
    HDAC3, histone deacetylase 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HDAC3, histone deacetylase 3
  • Synonyms
    HD3, KDAC3, RPD3, RPD3-2
  • Links
    NCBI Gene ID: 8841
    neXtProt AC: NX_O15379
    UniProt: O15379

  • Chr Location
    5q31.3; chr5:141620876-141636849 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Hdac3 mouse models; 1 with human HDAC3 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    58 phenotypes from 6 alleles in 10 genetic backgrounds
    106 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Disruption of this gene results in embryonic death at or around the time of gastrulation. Structural and functional abnormalities are also reported in mitochondria.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    128
  • GO References
    33
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    944
  • Tissues
    112
  • cDNA Data
    120
  • Literature Summary
    39
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15183 NCBI Gene Model | MGI Sequence Detail 18050 C57BL/6J ±  kb
    transcript NM_010411 RefSeq | MGI Sequence Detail 2005 ZRU/MplStud  
    polypeptide O88895 UniProt | EBI | MGI Sequence Detail 428 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 134
      Genomic 1
      cDNA 120
      Primer pair 11
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2147071
    References
    more
    • Summaries
      All 263
      Developmental Gene Expression 39
      Diseases 1
      Gene Ontology 33
      Phenotypes 106
    • Earliest
      J:56106 Mahlknecht U, et al., Assignment of the histone deacetylase gene (Hdac3) to mouse chromosome 18B3 by in situ hybridization. Cytogenet Cell Genet. 1999;84(3-4):192-3
    • Latest
      J:346765 Xu Y, et al., Hepatocyte-specific HDAC3 ablation promotes hepatocellular carcinoma in females by suppressing Foxa1/2. BMC Cancer. 2023 Sep 26;23(1):906
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory