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Tlr6 Gene Detail
Summary
  • Symbol
    Tlr6
  • Name
    toll-like receptor 6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341296
    NCBI Gene: 21899
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:65109374-65117440 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 33.54 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    48 from dbSNP Build 142
  • Strain Annotations
    17
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341296
 protein coding gene Chr5:65109374-65128387 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029569
 protein coding gene Chr5:64557978-64566638 (-)
A/J MGP_AJ_G0029537
 protein coding gene Chr5:62164743-62172820 (-)
AKR/J MGP_AKRJ_G0029485
 protein coding gene Chr5:64120281-64128868 (-)
BALB/cJ MGP_BALBcJ_G0029546
 protein coding gene Chr5:62850572-62859610 (-)
C3H/HeJ MGP_C3HHeJ_G0029269
 protein coding gene Chr5:64477001-64486161 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030000
 protein coding gene Chr5:67237310-67246460 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027240
 protein coding gene Chr5:58229701-58244182 (-)
CAST/EiJ MGP_CASTEiJ_G0028677
 protein coding gene Chr5:63563683-63579051 (-)
CBA/J MGP_CBAJ_G0029238
 protein coding gene Chr5:69398510-69408938 (-)
DBA/2J MGP_DBA2J_G0029384
 protein coding gene Chr5:62182630-62190697 (-)
FVB/NJ MGP_FVBNJ_G0029344
 protein coding gene Chr5:61369995-61378550 (-)
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0029372
 protein coding gene Chr5:72302421-72307295 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030033
 protein coding gene Chr5:63810966-63820632 (-)
PWK/PhJ MGP_PWKPhJ_G0028401
 protein coding gene Chr5:61157664-61165850 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028235
 protein coding gene Chr5:63118615-63128008 (-)
WSB/EiJ MGP_WSBEiJ_G0028757
 protein coding gene Chr5:64009502-64017998 (-)



Homology
more
  • Human Ortholog
    TLR6, toll like receptor 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TLR6, toll like receptor 6
  • Synonyms
    CD286
  • Links
    NCBI Gene ID: 10333
    neXtProt AC: NX_Q9Y2C9
    UniProt: Q9Y2C9

  • Chr Location
    4p14; chr4:38822897-38868390 (-)  GRCh38
Human Diseases
more
  • Diseases
    5 with human TLR6 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 5 alleles in 5 genetic backgrounds
    1 phenotype from multigenic genotypes
    79 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Inactivation of this gene results in abnormal macrophage function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    60
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    734
  • Tissues
    15
  • cDNA Data
    9
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000051498 Ensembl Gene Model | MGI Sequence Detail 8067 C57BL/6J ±  kb
    transcript ENSMUST00000239485 Ensembl | MGI Sequence Detail 2603 Not Applicable  
    polypeptide ENSMUSP00000159286 Ensembl | MGI Sequence Detail 806 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 10
      Primer pair 3

      Microarray probesets 3
    References
    more
    • Summaries
      All 133
      Developmental Gene Expression 7
      Gene Ontology 16
      Phenotypes 79
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:310855 Yiu JHC, et al., TLR5 Supports Development of Placental Labyrinthine Zone in Mice. Front Cell Dev Biol. 2021;9:711253
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory