About   Help   FAQ
Parp2 Gene Detail
Summary
  • Symbol
    Parp2
  • Name
    poly (ADP-ribose) polymerase family, member 2
  • Synonyms
    Adprt2, Adprtl2, Aspartl2, C78626, PARP-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341112
    NCBI Gene: 11546
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:51045347-51058758 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 26.25 cM, cytoband C1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    546 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341112
 protein coding gene Chr14:51045298-51058758 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021258
 protein coding gene Chr14:44758756-44771663 (+)
A/J MGP_AJ_G0021212
 protein coding gene Chr14:43422267-43436514 (+)
AKR/J MGP_AKRJ_G0021188
 protein coding gene Chr14:45051567-45065974 (+)
BALB/cJ MGP_BALBcJ_G0021215
 protein coding gene Chr14:43536045-43549158 (+)
C3H/HeJ MGP_C3HHeJ_G0020997
 protein coding gene Chr14:44876356-44893074 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021651
 protein coding gene Chr14:46571547-46598568 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019204
 protein coding gene Chr14:42761892-42776614 (+)
CAST/EiJ MGP_CASTEiJ_G0020521
 protein coding gene Chr14:41940193-41955365 (+)
CBA/J MGP_CBAJ_G0020964
 protein coding gene Chr14:48067775-48083944 (+)
DBA/2J MGP_DBA2J_G0021088
 protein coding gene Chr14:43318643-43332122 (+)
FVB/NJ MGP_FVBNJ_G0021069
 protein coding gene Chr14:42945239-42959273 (+)
LP/J MGP_LPJ_G0021156
 protein coding gene Chr14:45037421-45052032 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021097
 protein coding gene Chr14:47544128-47559383 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021681
 protein coding gene Chr14:44546842-44563567 (+)
PWK/PhJ MGP_PWKPhJ_G0020271
 protein coding gene Chr14:40217085-40230423 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020096
 protein coding gene Chr14:40706335-40719309 (+)
WSB/EiJ MGP_WSBEiJ_G0020574
 protein coding gene Chr14:44739534-44752675 (+)



Homology
more
  • Human Ortholog
    PARP2, poly(ADP-ribose) polymerase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PARP2, poly(ADP-ribose) polymerase 2
  • Synonyms
    ADPRT2, ADPRTL2, ADPRTL3, ARTD2, pADPRT-2, PARP-2
  • Links
    NCBI Gene ID: 10038
    UniProt: Q9UGN5

  • Chr Location
    14q11.2; chr14:20343615-20357904 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotypes from multigenic genotypes
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant animals are sensitive to gamma radiation. Epithelial crypt degeneration and DNA repair deficiency is apparent following radiation-induced injury. Homozygosity for a catalytically inactive mutant allele leads to DNA replication deficiencies in embryonic erythroblasts, resulting in impaired hematopoiesis, pale liver, liver hypoplasia, anemia and embryonic lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    101
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    747
  • Tissues
    38
  • cDNA Data
    43
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11546 NCBI Gene Model | MGI Sequence Detail 13412 C57BL/6J ±  kb
    transcript NR_185484 RefSeq | MGI Sequence Detail 2332 ZRU/MplStud  
    polypeptide O88554 UniProt | EBI | MGI Sequence Detail 559 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 47
      Genomic 1
      cDNA 43
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1353643
    References
    more
    • Summaries
      All 88
      Developmental Gene Expression 7
      Gene Ontology 17
      Phenotypes 38
    • Earliest
      J:54433 Berghammer H, et al., pADPRT-2: a novel mammalian polymerizing(ADP-ribosyl)transferase gene related to truncated pADPRT homologues in plants and Caenorhabditis elegans. FEBS Lett. 1999 Apr 23;449(2-3):259-63
    • Latest
      J:358182 Lin X, et al., Inactive Parp2 causes Tp53-dependent lethal anemia by blocking replication-associated nick ligation in erythroblasts. Mol Cell. 2024 Oct 17;84(20):3916-3931.e7
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    01/28/2026
    MGI 6.24     		The Jackson Laboratory