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Adgrg1 Gene Detail
Summary
  • Symbol
    Adgrg1
  • Name
    adhesion G protein-coupled receptor G1
  • Synonyms
    Cyt28, Gpr56
  • Feature Type
    protein coding gene
  • IDs
    MGI:1340051
    NCBI Gene: 14766
  • Alliance
    genome feature page
  • Transcription Start Sites
    35 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:95701379-95740845 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 47.12 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1208 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1340051
 protein coding gene Chr8:95701321-95740845 (+)
129S1/SvImJ ENSMUSG00200016795
 protein coding gene Chr8:90062490-90102481 (+)
A/J ENSMUSG00195027903
 protein coding gene Chr8:90415689-90455697 (+)
AKR/J ENSMUSG00220036452
 protein coding gene Chr8:90452506-90492518 (+)
BALB/cJ ENSMUSG00180017976
 protein coding gene Chr8:90299381-90339374 (+)
C3H/HeJ ENSMUSG00175024847
 protein coding gene Chr8:90358885-90398891 (+)
C57BL/6NJ ENSMUSG00215013639
 protein coding gene Chr8:89973609-90013629 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031413
 protein coding gene Chr8:86467998-86506003 (+)
CAST/EiJ ENSTCUG00005015706
 protein coding gene Chr8:89820043-89860031 (+)
CBA/J ENSMUSG00210031077
 protein coding gene Chr8:90293200-90333246 (+)
DBA/2J ENSMUSG00185022283
 protein coding gene Chr8:96402073-96442106 (+)
FVB/NJ ENSMUSG00205013236
 protein coding gene Chr8:89386831-89426830 (+)
JF1/MsJ ENSUMUG00000040034
 protein coding gene Chr8:98753746-98793733 (+)
LP/J ENSMUSG00230027265
 protein coding gene Chr8:100056471-100096476 (+)
NOD/ShiLtJ ENSMUSG00190014962
 protein coding gene Chr8:90424866-90464895 (+)
NZO/HlLtJ ENSMUSG00225011210
 protein coding gene Chr8:103452462-103492416 (+)
PWK/PhJ ENSLUMG00010033758
 protein coding gene Chr8:90146839-90187458 (+)
SPRET/EiJ ENSMSPG00010005840
 protein coding gene Chr8:92153020-92192957 (+)
WSB/EiJ ENSIUOG00005018116
 protein coding gene Chr8:91128153-91168131 (+)



Homology
more
  • Human Ortholog
    ADGRG1, adhesion G protein-coupled receptor G1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADGRG1, adhesion G protein-coupled receptor G1
  • Synonyms
    BFPP, BPPR, CDCBM14B, CDCBM15A, GPR56, TM7LN4, TM7XN1
  • Links
    NCBI Gene ID: 9289
    UniProt: Q9Y653

  • Chr Location
    16q21; chr16:57610652-57665580 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human ADGRG1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 4 alleles in 5 genetic backgrounds
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit defects in basement membranes of mutltiple tissues, resulting in neuronal ectopias in the frontoparietal cortex, male subfertility and testis defects, brain development, and hematopoietic stem cell development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    87
  • GO References
    23
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1192
  • Tissues
    139
  • cDNA Data
    136
  • Literature Summary
    23
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031785 Ensembl Gene Model | MGI Sequence Detail 39467 C57BL/6J ±  kb
    transcript ENSMUST00000093271 Ensembl | MGI Sequence Detail 3574 Not Applicable  
    polypeptide ENSMUSP00000090959 Ensembl | MGI Sequence Detail 687 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 144
      Genomic 1
      cDNA 138
      Primer pair 3
      Other 2
      Antibodies 6

      Microarray probesets 5
    References
    more
    • Summaries
      All 96
      Developmental Gene Expression 23
      Gene Ontology 23
      Phenotypes 41
    • Earliest
      J:53199 Liu M, et al., GPR56, a novel secretin-like human G-protein-coupled receptor gene. Genomics. 1999 Feb 1;55(3):296-305
    • Latest
      J:380958 Jang YJ, et al., Cooperative role of CD81 with GPR56 and collagen III in cortical formation. Neurosci Res. 2026 Feb 20;225:105035
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory