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Fem1b Gene Detail
Summary
  • Symbol
    Fem1b
  • Name
    fem 1 homolog b
  • Synonyms
    mKIAA0396
  • Feature Type
    protein coding gene
  • IDs
    MGI:1335087
    NCBI Gene: 14155
  • Alliance
    genome feature page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:62699106-62718930 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 33.87 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    333 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1335087
 protein coding gene Chr9:62699103-62719216 (-)
129S1/SvImJ ENSMUSG00200033922
 protein coding gene Chr9:59806366-59826463 (-)
A/J ENSMUSG00195039993
 protein coding gene Chr9:59514517-59534576 (-)
AKR/J ENSMUSG00220026932
 protein coding gene Chr9:59663878-59684209 (-)
BALB/cJ ENSMUSG00180015317
 protein coding gene Chr9:59648223-59668340 (-)
C3H/HeJ ENSMUSG00175019368
 protein coding gene Chr9:59647640-59667702 (-)
C57BL/6NJ ENSMUSG00215030183
 protein coding gene Chr9:59635387-59655508 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032326
 protein coding gene Chr9:59952758-59971893 (-)
CAST/EiJ ENSTCUG00005020345
 protein coding gene Chr9:59558555-59578382 (-)
CBA/J ENSMUSG00210032485
 protein coding gene Chr9:59737622-59757727 (-)
DBA/2J ENSMUSG00185036505
 protein coding gene Chr9:59760858-59780954 (-)
FVB/NJ ENSMUSG00205035473
 protein coding gene Chr9:60084926-60104986 (-)
JF1/MsJ ENSUMUG00000037183
 protein coding gene Chr9:59806277-59826611 (-)
LP/J ENSMUSG00230033479
 protein coding gene Chr9:60005633-60025727 (-)
NOD/ShiLtJ ENSMUSG00190038813
 protein coding gene Chr9:59844134-59864195 (-)
NZO/HlLtJ ENSMUSG00225027027
 protein coding gene Chr9:60070429-60090490 (-)
PWK/PhJ ENSLUMG00010035282
 protein coding gene Chr9:59772646-59792982 (-)
SPRET/EiJ ENSMSPG00010024766
 protein coding gene Chr9:60836217-60855167 (-)
WSB/EiJ ENSIUOG00005037681
 protein coding gene Chr9:59252056-59272162 (-)



Homology
more
  • Human Ortholog
    FEM1B, fem-1 homolog B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FEM1B, fem-1 homolog B
  • Synonyms
    F1AA, F1A-ALPHA, FEM1-beta, NEDBES
  • Links
    NCBI Gene ID: 10116
    UniProt: Q9UK73

  • Chr Location
    15q23; chr15:68277745-68295862 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Fem1b mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous targeted mutants display abnormal glucose tolerance due to defective glucose-stimulated insulin secretion.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    50
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    683
  • Tissues
    80
  • cDNA Data
    22
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14155 NCBI Gene Model | MGI Sequence Detail 19825 C57BL/6J ±  kb
    transcript NM_010193 RefSeq | MGI Sequence Detail 6505 ZRU/MplStud  
    polypeptide Q9Z2G0 UniProt | EBI | MGI Sequence Detail 627 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 23

      Microarray probesets 6
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 13
      Phenotypes 12
    • Earliest
      J:51387 Ventura-Holman T, et al., The murine fem1 gene family: homologs of the Caenorhabditis elegans sex- determination protein FEM-1. Genomics. 1998 Dec 1;54(2):221-30
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory